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哮喘患者中 FSTL1 表达与气道重塑的相关性。

The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics.

机构信息

Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, China.

Department of Pulmonary Medicine-Bronchoscopy Room, Qilu Hospital of Shandong University, Jinan 250012, China.

出版信息

Mediators Inflamm. 2017;2017:7918472. doi: 10.1155/2017/7918472. Epub 2017 Aug 3.

DOI:10.1155/2017/7918472
PMID:28845090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5560092/
Abstract

BACKGROUND

Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma.

OBJECTIVES

To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma.

METHODS

We examined FSTL1 levels in 32 asthmatics and 25 controls. All subjects enrolled had routine blood tests, spirometry, and impulse oscillometry performed. Additionally, 15 of the 32 asthmatics underwent fibre optic bronchoscopy. Spearman rank analysis was performed to detect the correlation between FSTL1 and other parameters.

RESULTS

Plasma FSTL1 levels were higher in asthmatics (130.762 ± 46.029 ng/mL) than in controls (95.408 ± 33.938 ng/mL) ( = 0.009). Plasma FSTL1 levels were associated with fibrosis levels around the airways (rs = 0.529, = 0.043) and -smooth muscle actin (-SMA) (rs = 0.554, = 0.032). FSTL1 levels in bronchoalveolar lavage fluid were associated with collagen I (rs = 0.536, = 0.040), -SMA (rs = 0.561, = 0.029), fibrosis levels (rs = 0.779, = 0.001), and the thickness of the airway reticular basement membrane (RBM) (rs = 0.660, = 0.007).

CONCLUSIONS

FSTL1 levels in asthmatics were linked with increased smooth muscle mass and thickened RBM. FSTL1 may contribute to airway remodeling in asthmatics.

摘要

背景

哮喘的特征是气道重塑。卵泡抑素样蛋白 1（FSTL1）是一种细胞外糖蛋白。最近的研究表明，FSTL1 可能参与哮喘的发病机制。

目的

分析 FSTL1 与某些参数之间的关联，并观察 FSTL1 在哮喘中的作用。

方法

我们检测了 32 例哮喘患者和 25 例对照者的 FSTL1 水平。所有入组患者均进行了常规血液检查、肺功能检查和脉冲振荡检查。此外，32 例哮喘患者中的 15 例行纤维支气管镜检查。采用 Spearman 秩相关分析检测 FSTL1 与其他参数之间的相关性。

结果

哮喘患者的血浆 FSTL1 水平（130.762 ± 46.029 ng/mL）高于对照组（95.408 ± 33.938 ng/mL）（ = 0.009）。血浆 FSTL1 水平与气道周围纤维化水平（rs = 0.529， = 0.043）和 -平滑肌肌动蛋白（-SMA）（rs = 0.554， = 0.032）呈正相关。支气管肺泡灌洗液中的 FSTL1 水平与胶原 I（rs = 0.536， = 0.040）、-SMA（rs = 0.561， = 0.029）、纤维化水平（rs = 0.779， = 0.001）和气道网状基底膜（RBM）厚度（rs = 0.660， = 0.007）呈正相关。

结论

哮喘患者的 FSTL1 水平与平滑肌质量增加和 RBM 增厚有关。FSTL1 可能参与哮喘患者的气道重塑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a9/5560092/1a5dc956a342/MI2017-7918472.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a9/5560092/79c01e8e0b4d/MI2017-7918472.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a9/5560092/1a5dc956a342/MI2017-7918472.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a9/5560092/79c01e8e0b4d/MI2017-7918472.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a9/5560092/618a4bb7802f/MI2017-7918472.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a9/5560092/15580b015407/MI2017-7918472.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a9/5560092/df1a1c24aff1/MI2017-7918472.004.jpg
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