Chaly Yury, Hostager Bruce, Smith Sonja, Hirsch Raphael
Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, 2191 ML, 500 Newton Road, Iowa City, IA, 52242, USA,
Immunol Res. 2014 Aug;59(1-3):266-72. doi: 10.1007/s12026-014-8526-z.
Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein produced mainly by cells of mesenchymal origin. FSTL1 has been shown to play an important role during embryogenesis; FSTL1-deficient mice die at birth from multiple developmental abnormalities. In the last decade, FSTL1 has been identified as a novel inflammatory protein, enhancing synthesis of proinflammatory cytokines and chemokines by immune cells in vitro and in vivo. FSTL1 mediates proinflammatory events in animal models of inflammatory diseases, particularly in collagen-induced arthritis in mice. FSTL1 is elevated in various inflammatory conditions and decreased during the course of treatment. FSTL1 may therefore be a valuable biomarker for such diseases. Moreover, a variety of experiments suggest that targeting of FSTL1 may be useful in the treatment of diseases in which inflammation plays a central role.
卵泡抑素样蛋白1（FSTL1）是一种主要由间充质来源的细胞产生的分泌型糖蛋白。FSTL1已被证明在胚胎发育过程中发挥重要作用；FSTL1基因缺陷的小鼠出生时因多种发育异常而死亡。在过去十年中，FSTL1已被鉴定为一种新型炎症蛋白，在体外和体内均可增强免疫细胞促炎细胞因子和趋化因子的合成。FSTL1在炎症性疾病的动物模型中介导促炎事件，尤其是在小鼠胶原诱导的关节炎中。FSTL1在各种炎症状态下升高，在治疗过程中降低。因此，FSTL1可能是此类疾病的一个有价值的生物标志物。此外，各种实验表明，靶向FSTL1可能对治疗炎症起核心作用的疾病有用。
