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雷珠单抗治疗脉络膜骨瘤及继发性脉络膜新生血管

Choroidal Osteoma and Secondary Choroidal Neovascularization Treated with Ranibizumab.

作者信息

Sarıgül Sezenöz Almila, Akça Bayar Sezin, Yılmaz Gürsel

机构信息

Başkent University Hospital, Ophthalmology Clinic, Ankara, Turkey.

出版信息

Turk J Ophthalmol. 2017 Aug;47(4):243-246. doi: 10.4274/tjo.86658. Epub 2017 Aug 15.

DOI:10.4274/tjo.86658
PMID:28845332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5563556/
Abstract

A 47-year-old female patient presented with a complaint of decreased vision in the right eye. Her visual acuity was 0.16 in the right eye and 1.0 in the left eye. Fundus examination revealed a slightly elevated, yellowish-white lesion with regular borders at the macula of the right eye. Early and late hyperfluorescence related with choroidal neovascularization (CNV) was detected in the right eye on fundus fluorescein angiography. B-scan ultrasonography revealed a hyperechoic choroidal lesion with acoustic shadowing. The lesion was diagnosed as choroidal osteoma. The patient received 3 injections of intravitreal ranibizumab. After 4 months, the visual acuity of the right eye was 0.9 and the CNV had regressed. Follow-up at about 7 months revealed reduced visual acuity in the right eye with an increase in subretinal fluid. An additional ranibizumab injection was administered. In this case report, we discuss the findings and treatment of a rare case of choroidal osteoma with secondary CNV.

摘要

一名47岁女性患者因右眼视力下降前来就诊。她右眼视力为0.16，左眼视力为1.0。眼底检查发现右眼黄斑区有一个边界规则、略隆起的黄白色病变。眼底荧光血管造影显示右眼存在与脉络膜新生血管（CNV）相关的早期和晚期高荧光。B超检查显示脉络膜病变呈高回声且有声影。该病变被诊断为脉络膜骨瘤。患者接受了3次玻璃体内注射雷珠单抗。4个月后，右眼视力为0.9，CNV消退。约7个月的随访显示右眼视力下降，视网膜下液增多。遂又注射了一次雷珠单抗。在本病例报告中，我们讨论了一例罕见的伴有继发性CNV的脉络膜骨瘤的检查结果及治疗情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee15/5563556/0d20378da61a/TJO-47-243-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee15/5563556/7ff04b9344bb/TJO-47-243-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee15/5563556/138a8a0c38ea/TJO-47-243-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee15/5563556/028e75d671b4/TJO-47-243-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee15/5563556/adf409400ee7/TJO-47-243-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee15/5563556/0d20378da61a/TJO-47-243-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee15/5563556/7ff04b9344bb/TJO-47-243-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee15/5563556/138a8a0c38ea/TJO-47-243-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee15/5563556/028e75d671b4/TJO-47-243-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee15/5563556/adf409400ee7/TJO-47-243-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee15/5563556/0d20378da61a/TJO-47-243-g5.jpg

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J Ophthalmol. 2014;2014:210458. doi: 10.1155/2014/210458. Epub 2014 Jul 23.
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Long-term results of intravitreal ranibizumab for osteoma-related choroidal neovascularization in a child.玻璃体内注射雷珠单抗治疗儿童骨瘤相关性脉络膜新生血管的长期结果
Oman J Ophthalmol. 2014 May;7(2):78-80. doi: 10.4103/0974-620X.137162.
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Long-Term Follow-Up of Intravitreal Ranibizumab for the Treatment of Choroidal Neovascularization due to Choroidal Osteoma.
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Case Rep Ophthalmol. 2012 May;3(2):200-4. doi: 10.1159/000339624. Epub 2012 Jun 12.
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