Muresan Lucian, Petcu Ana, Muresan Crina, Rinzis Mirela, Gusetu Gabriel, Pop Dana, Zdrenghea Dumitru, Rednic Simona
Cardiology Dept. Rehabilitation Hospital, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Rheumatology Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Iran J Public Health. 2017 Jul;46(7):906-916.
In patients with systemic sclerosis, NT-proBNP is a useful diagnostic marker for pulmonary hypertension and ventricular dysfunction, with important prognostic significance. The aim of this study was to assess the relationship between the NT-proBNP levels and the presence and severity of ventricular arrhythmias in patients with scleroderma.
Forty consecutive patients with a diagnostic of systemic sclerosis according to the EULAR criteria admitted at the Rheumatology Clinic of Cluj-Napoca, Romania, from Jan 2014 to Apr 2014 were enrolled. Patients underwent a 12-lead ECG and a 24-hour Holter ECG monitoring for ventricular arrhythmias evaluation. Blood sample testing (including NT-proBNP level measurements), echocardiography, spirometry, chest X-ray and, when considered appropriate, high-resolution chest CT were performed.
Sixty percent of patients (n=24) had abnormal NT-proBNP serum levels (>125 pg/ml) and 10 patients had >100 PVC/24 h. There was a statistically significant correlation between the NT-proBNP levels and the total number of premature ventricular contractions (PVC) (r=0.445, =0.006), total number of isolated PVC (r=0,493, =0.002), total number of ventricular couplets (r=0.379, =0.021) and the number of PVC morphologies (r=0.501, =0.002). The presence of an NT-proBNP serum level >287 pg/ml had a sensitivity of 55% and a specificity of 93% in predicting the presence of complex ventricular arrhythmias on 24-hour Holter ECG monitoring.
NT-proBNP levels could become a useful ventricular arrhythmia marker for assessing the arrhythmic risk in patients with systemic sclerosis.
在系统性硬化症患者中，N末端B型利钠肽原（NT-proBNP）是肺动脉高压和心室功能障碍的有用诊断标志物，具有重要的预后意义。本研究的目的是评估系统性硬化症患者NT-proBNP水平与室性心律失常的存在及严重程度之间的关系。
纳入2014年1月至2014年4月在罗马尼亚克卢日-纳波卡风湿病诊所根据欧洲抗风湿病联盟（EULAR）标准诊断为系统性硬化症的40例连续患者。患者接受12导联心电图和24小时动态心电图监测以评估室性心律失常。进行血液样本检测（包括NT-proBNP水平测量）、超声心动图、肺功能测定、胸部X线检查，以及在认为合适时进行高分辨率胸部CT检查。
60%的患者（n = 24）NT-proBNP血清水平异常（>125 pg/ml），10例患者每24小时室性早搏（PVC）>100次。NT-proBNP水平与室性早搏总数（PVC）（r = 0.445，P = 0.006）、孤立性PVC总数（r = 0.493，P = 0.002）、室性二联律总数（r = 0.379，P = 0.021）以及PVC形态数量（r = 0.501，P = 0.002）之间存在统计学显著相关性。NT-proBNP血清水平>287 pg/ml在预测24小时动态心电图监测中复杂性室性心律失常的存在方面，敏感性为55%，特异性为
