利咪唑（BW 234 U）与小鼠脑内局部单胺浓度

Rimcazole (BW 234 U) and regional monoamine concentrations in mouse brain.

作者信息

Hadfield M G, Milio C

出版信息

Life Sci. 1987 May 25;40(21):2087-90. doi: 10.1016/0024-3205(87)90101-9.

Abstract

Rimcazole (BW 234 U), a novel agent with antipsychotic potential, was administered i.p. (50 mg/kg) to adult male ICR mice 30 minutes before brain removal. Regional HPLC analysis of central monoamine levels showed no change in the DOPAC/DA ratio for any tissue as compared with values obtained from control saline treated animals. However, the MHPG/NE ratio was increased in the septum, striatum, hypothalamus and thalamus and there was a reciprocal decrease in the 5HIAA/5HT ratio in the septum. The data are consistent with a known lack of rimcazole affinity for dopamine receptors and indicate the involvement of alternate neurotransmitter systems in the actions of this drug.

摘要

利咪唑（BW 234 U）是一种具有抗精神病潜力的新型药物，在处死成年雄性ICR小鼠前30分钟腹腔注射（50毫克/千克）。对中枢单胺水平进行的区域高效液相色谱分析显示，与接受生理盐水处理的对照动物相比，任何组织的3,4-二羟基苯乙酸/多巴胺（DOPAC/DA）比值均无变化。然而，中隔、纹状体、下丘脑和丘脑的3-甲氧基-4-羟基苯乙二醇/去甲肾上腺素（MHPG/NE）比值升高，中隔的5-羟吲哚乙酸/5-羟色胺（5HIAA/5HT）比值则相应降低。这些数据与利咪唑对多巴胺受体缺乏亲和力这一已知情况相符，并表明该药物的作用涉及其他神经递质系统。