Freeman G B, Gibson G E
Neurobiol Aging. 1987 Mar-Apr;8(2):147-52. doi: 10.1016/0197-4580(87)90024-8.
The release of acetylcholine (ACh), glutamate (GLU) and dopamine (DA) from various brain regions was investigated in young (3 month) and old (30 month) Balb/c mice. Aging increased the basal release of GLU (77%) and DA (29%) in striatum and GLU in hippocampus (94%); the concentrations of these neurotransmitters in the media after K+ stimulation were unaltered by aging. Although the basal release of ACh was not altered by age, K+-stimulated ACh release was reduced in striatum. The age-related increases in basal GLU and DA release may be important in the pathophysiology of cell death during aging.
研究了年轻（3个月）和年老（30个月）的Balb/c小鼠不同脑区乙酰胆碱（ACh）、谷氨酸（GLU）和多巴胺（DA）的释放情况。衰老增加了纹状体中GLU（77%）和DA（29%）以及海马体中GLU（94%）的基础释放量；衰老并未改变K⁺刺激后培养基中这些神经递质的浓度。虽然ACh的基础释放量不受年龄影响，但纹状体中K⁺刺激的ACh释放量减少。基础GLU和DA释放量随年龄增长而增加可能在衰老过程中细胞死亡的病理生理学中起重要作用。
