Freeman G B, Gibson G E
Cornell University Medical College, Burke Rehabilitation Center, White Plains, New York 10605.
Ann N Y Acad Sci. 1988;515:191-202. doi: 10.1111/j.1749-6632.1988.tb32984.x.
Aging, hypoxia, and thiamin deficiency diminish motor performance. Similar alterations of ACh, DA, and glutamate metabolism accompany hypoxia, thiamin deficiency, and aging. Both aging and hypoxia reduce ACh release and stimulate DA and glutamate release. Presynaptic enhancement of DA and glutamate release may be important in the production of cell damage that may contribute, in part, to age-related deficits in motor as well as cognitive function. The decline in ACh release may be important in the production of the cognitive deficits. An understanding of the interactions of neurotransmitters in hypoxia and thiamin deficiency aids our understanding of normal aging and increases the possibility of developing better treatments for the multiple neurotransmitter deficiencies that accompany many metabolic, age-related, and chronic degenerative disorders.
衰老、缺氧和硫胺素缺乏会降低运动能力。缺氧、硫胺素缺乏和衰老会伴随乙酰胆碱、多巴胺和谷氨酸代谢的类似改变。衰老和缺氧都会减少乙酰胆碱的释放，并刺激多巴胺和谷氨酸的释放。多巴胺和谷氨酸释放的突触前增强可能在细胞损伤的产生中起重要作用，这可能部分导致与年龄相关的运动和认知功能缺陷。乙酰胆碱释放的减少可能在认知缺陷的产生中起重要作用。了解缺氧和硫胺素缺乏时神经递质的相互作用有助于我们理解正常衰老，并增加开发更好治疗方法的可能性，以治疗伴随许多代谢、年龄相关和慢性退行性疾病的多种神经递质缺乏症。
