Peroutka S J, Kitamura K, Lim M, Steinman L
Neurology. 1987 Jun;37(6):1068-72. doi: 10.1212/wnl.37.6.1068.
We studied mortality after pertussis immunization in the mouse. Without treatment, 73 of 92 animals (80%) died after injection of bovine serum albumin (BSA) on day +7 of pertussis immunization. After pretreatment with 3 mg of cyproheptadine, 2 mg mianserin, or 2 mg chlorpheniramine, only 5 of 105 animals (5%) died after receiving BSA on day +7 (p less than 0.001). Blockade of histamine H1 receptors may reduce mortality in pertussis immunization-induced encephalopathy in mice.
我们研究了小鼠百日咳免疫后的死亡率。未经治疗的情况下，92只动物中有73只（80%）在百日咳免疫第7天注射牛血清白蛋白（BSA）后死亡。用3毫克赛庚啶、2毫克米安色林或2毫克氯苯那敏预处理后，105只动物中只有5只（5%）在第7天接受BSA后死亡（p<0.001）。组胺H1受体的阻断可能降低小鼠百日咳免疫诱导的脑病的死亡率。
