Redhead K, Robinson A, Ashworth L A, Melville-Smith M
Division of Bacteriology, National Institute for Biological Standards and Control, Hampstead, London, UK.
J Biol Stand. 1987 Oct;15(4):341-51. doi: 10.1016/s0092-1157(87)80007-0.
A murine encephalopathic syndrome can be induced by the administration of BSA and whole-cell pertussis vaccine. The present paper reports studies of the capacity of purified individual pertussis components to induce this effect. Pertussis toxin and endotoxin together with a highly immunogenic sensitizer protein were required to induce the effect. The strength of the antibody response to the sensitizer appeared to be more important than the H-2 type of the recipient in determining the susceptibility of different mouse strains. The relevance of this syndrome to the study of possible vaccine-induced encephalopathy in man is uncertain and requires further investigation.
通过注射牛血清白蛋白（BSA）和全细胞百日咳疫苗可诱发小鼠脑病综合征。本文报告了关于纯化的单个百日咳成分诱发此效应能力的研究。百日咳毒素、内毒素以及一种高免疫原性致敏蛋白共同作用才能诱发该效应。在确定不同小鼠品系的易感性时，对致敏剂的抗体反应强度似乎比受体的H-2类型更为重要。该综合征与人类疫苗诱导性脑病研究的相关性尚不确定，需要进一步研究。
