Department of Chemistry and Biochemistry, Northern Illinois University , DeKalb, Illinois 60115, United States.
J Org Chem. 2017 Oct 6;82(19):10219-10225. doi: 10.1021/acs.joc.7b01724. Epub 2017 Sep 18.
Michael addition has been achieved with a variety of amino acid esters and 2- or 4-vinylpyridine. Similar reactions were accomplished with an alkenyl-substituted pyrimidine, pyrazine, thiazole, quinoxaline, benzoxazole, and quinolone. In reactions at a prochiral center, modest diastereoselectivities were observed with the formation of the new stereogenic carbon. NMR experiments indicate that the addition reaction is reversible under acidic conditions.
迈克尔加成反应已经在各种氨基酸酯和 2-或 4-乙烯基吡啶上实现。类似的反应也在烯基取代的嘧啶、吡嗪、噻唑、喹喔啉、苯并恶唑和喹诺酮上完成。在手性中心的反应中，新的手性碳原子的形成观察到了适度的非对映选择性。NMR 实验表明，在酸性条件下，加成反应是可逆的。
