华法林类似物的合成：烯基取代的氮杂环与4-羟基香豆素及相关底物的共轭加成反应。
Synthesis of warfarin analogs: conjugate addition reactions of alkenyl-substituted N-heterocycles with 4-hydroxycoumarin and related substrates.
作者信息
Goka Benjamin, Klumpp Douglas A
机构信息
Department of Chemistry and Biochemistry, Northern Illinois University DeKalb Illinois 60115 USA
出版信息
RSC Adv. 2023 Feb 6;13(7):4754-4756. doi: 10.1039/d3ra00251a. eCollection 2023 Jan 31.
Abstract
We have developed a procedure for the Michael addition of 4-hydroxycoumarins to vinyl-substituted N-heterocycles. The chemistry is also suitable for thiocoumarins and quinolinones. A mechanism is proposed involving nucleophilic attack at the vinyl-group of the protonated N-heterocycle.
摘要
我们已经开发出一种用于将4-羟基香豆素与乙烯基取代的N-杂环进行迈克尔加成反应的方法。该化学方法也适用于硫代香豆素和喹啉酮。提出了一种涉及对质子化N-杂环的乙烯基进行亲核进攻的机理。
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