Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University , Hangzhou 311121, P. R. China.
Suzhou Research Institute and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, P. R. China.
Org Lett. 2017 Sep 15;19(18):4896-4899. doi: 10.1021/acs.orglett.7b02378. Epub 2017 Aug 28.
The enantioselective construction of a family of chiral glycine-derived aldimino esters is described. The asymmetric tandem conjugate addition-elimination procedure is characterized by its exceptional mild reaction conditions and features with an exquisite enantioselectivity profile using commercially available silver/DTBM-SegPhos catalyst, allowing for the facile preparation of a variety of substituted and chiral glutamic acid derivatives (up to 99% ee) bearing Schiff base in a straightforward manner.
描述了一类手性甘氨酸衍生亚氨基酯的对映选择性构建。不对称串联共轭加成-消除反应过程的特点是反应条件非常温和，并具有使用市售的银/ DTBM-SegPhos 催化剂获得的出色对映选择性，可方便地制备各种取代的和手性的谷氨酸衍生物（高达 99%的对映体过量），这些衍生物带有席夫碱，合成路线简单。
