State Key Laboratory of Physical Chemistry of Solid Surfaces & Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen 361005, China.
College of Chemistry & Materials Science, Longyan University , Fujian 364000, China.
J Org Chem. 2017 Oct 6;82(19):10149-10157. doi: 10.1021/acs.joc.7b01612. Epub 2017 Sep 11.
An efficient yttrium-catalyzed tandem intermolecular hydroalkoxylation/Claisen rearrangement has been developed, providing various γ,δ-unsaturated amides in generally good to excellent yields. Importantly, high Z/E selectivity and diastereoselectivity were achieved. Other notable features of this method include widespread availability of the substrates, compatibility with a broad range of functional groups, and mild reaction conditions.
一种高效的钇催化的串联分子间氢烷氧基化/克莱森重排反应已被开发出来，能够以通常良好到优秀的产率得到各种γ,δ-不饱和酰胺。重要的是，该方法实现了高 Z/E 选择性和非对映选择性。该方法的其他显著特点包括底物的广泛可用性、与广泛的官能团的兼容性以及温和的反应条件。
