氧化石墨烯-氧化铁纳米复合材料作为 Aβ42 淀粉样肽聚集的抑制剂。
Graphene oxide-iron oxide nanocomposite as an inhibitor of Aβ 42 amyloid peptide aggregation.
机构信息
CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, CAS center for Excellence in Nanoscience, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, 100190, PR China.
CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, CAS center for Excellence in Nanoscience, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, 100190, PR China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing, 100190, PR China.
出版信息
Colloids Surf B Biointerfaces. 2017 Nov 1;159:540-545. doi: 10.1016/j.colsurfb.2017.08.020. Epub 2017 Aug 18.
Inhibiting amyloid β (Aβ) aggregation has drawn much attention because it is one of the main reasons for the cause of Alzheimer's disease (AD). Here we have synthesized a nanocomposite of graphene oxide-iron oxide (GOIO) and demonstrated its ability of modulating Aβ aggregation. The inhibition effects of the GOIO nanocomposite on Aβ aggregates was studied by Thioflavin T fluorescence assay, circular dichroism and transmission electron microscopy, respectively. Furthermore, the cell viability study revealed that the GOIO nanocomposite can reduce the toxicity of Aβ fibrils to neuroblastoma cells. Our results demonstrated that the combination of GO and IO as a nanocomposite material has a potential use for the design new therapeutic agents for the treatment of Alzheimer's disease.
抑制淀粉样蛋白 β（Aβ）聚集引起了广泛关注，因为它是导致阿尔茨海默病（AD）的主要原因之一。在这里，我们合成了一种氧化石墨烯-氧化铁（GOIO）纳米复合材料，并证明了它调节 Aβ聚集的能力。通过噻唑蓝荧光测定法、圆二色性和透射电子显微镜分别研究了 GOIO 纳米复合材料对 Aβ 聚集体的抑制作用。此外，细胞活力研究表明，GOIO 纳米复合材料可以降低 Aβ 纤维对神经母细胞瘤细胞的毒性。我们的结果表明，GO 和 IO 的组合作为一种纳米复合材料具有用于设计治疗阿尔茨海默病的新型治疗剂的潜力。
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