Sergentanis Theodoros N, Psaltopoulou Theodora, Ntanasis-Stathopoulos Ioannis, Liaskas Athanasios, Tzanninis Ioannis-Georgios, Dimopoulos Meletios-Athanasios
a Department of Hygiene, Epidemiology and Medical Statistics , School of Medicine, National and Kapodistrian University of Athens , Athens , Greece.
b Department of Clinical Therapeutics , Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens , Athens , Greece.
Leuk Lymphoma. 2018 Feb;59(2):434-447. doi: 10.1080/10428194.2017.1339873. Epub 2017 Aug 28.
We examined the association between fruit/vegetable consumption and the risk of hematological malignancies in cohort studies (end of search: August 31, 2016). Total fruit consumption was not associated with the risk of non-Hodgkin lymphoma (NHL) (RR = 1.03, 95% CI: 0.92-1.16, I = 12.1%, n = 7), acute myeloid leukemia (RR = 1.23, 95% CI: 0.94-1.61, I = 0%, n = 3), multiple myeloma (MM; RR = 1.05, 95% CI: 0.72-1.55, I = 60.0%, n = 4), and Hodgkin lymphoma. However, citrus fruit consumption was associated with reduced NHL risk (RR = 0.85, 95% CI: 0.73-1.00, p = .044, I = 0%, n = 6). Vegetable intake was marginally associated with reduced NHL risk (RR = 0.89, 95% CI: 0.79-1.00, p = .056, I = 16.2%, n = 7), but not with acute myeloid leukemia, multiple myeloma, and Hodgkin lymphoma risk. Nevertheless, NHL risk was inversely associated with cruciferous vegetable consumption (RR = 0.84, 95% CI: 0.71-1.00, p = .047, I = 0%, n = 3). Notably, combined fruit/vegetable consumption was associated with decreased NHL risk (RR = 0.79, 95% CI: 0.65-0.96, I = 11.2%, n = 3). This meta-analysis reveals possible protective effects; however, confounding and reporting bias could have affected the results.
我们在队列研究中（检索截止日期：2016年8月31日）研究了水果/蔬菜摄入量与血液系统恶性肿瘤风险之间的关联。水果总摄入量与非霍奇金淋巴瘤（NHL）风险无关（风险比[RR]=1.03，95%置信区间[CI]：0.92 - 1.16，异质性指数[I]=12.1%，研究数量[n]=7）、急性髓系白血病（RR = 1.23，95% CI：0.94 - 1.61，I = 0%，n = 3）、多发性骨髓瘤（MM；RR = 1.05，95% CI：0.72 - 1.55，I = 60.0%，n = 4）以及霍奇金淋巴瘤风险均无关。然而，柑橘类水果摄入量与降低NHL风险相关（RR = 0.85，95% CI：0.73 - 1.00，p = 0.044，I = 0%，n = 6）。蔬菜摄入量与降低NHL风险存在微弱关联（RR = 0.89，95% CI：0.79 - 1.00，p = 0.056，I = 16.2%，n = 7），但与急性髓系白血病、多发性骨髓瘤和霍奇金淋巴瘤风险无关。尽管如此，NHL风险与十字花科蔬菜摄入量呈负相关（RR = 0.84，95% CI：0.71 - 1.00，p = 0.047，I = 0%，n = 3）。值得注意的是，水果/蔬菜联合摄入量与降低NHL风险相关（RR = 0.79，95% CI：0.65 - 0.96，I = 11.2%，n = 3）。这项荟萃分析揭示了可能的保护作用；然而，混杂因素和报告偏倚可能影响了研究结果。
