Tumanova I G, Sigidin Ia A
Ter Arkh. 1987;59(4):80-3.
A long-term comparative study of the classic basic drug-d-Penicillamin and 2 new sulfa drugs: sulfasalazin and salazopyridazin used for the first time in rheumatology, was conducted. Both drugs were shown to produce a "basic" effect in rheumatoid arthritis and to exceed d-Penicillamin in their therapeutic action. Better results were obtained with salazopyridazin. The tolerance to the new antirheumatic sulfa drugs was quite satisfactory; no severe side-effects were noted. Both drugs extend the potentialities of antirheumatoid therapy of prolonged action and warrant further use and study.
对经典基础药物d-青霉胺以及两种首次用于风湿病学的新型磺胺类药物——柳氮磺胺吡啶和水杨酸偶氮哒嗪进行了一项长期对比研究。结果表明，这两种药物在类风湿性关节炎中均产生了“基础”效应，且治疗作用超过了d-青霉胺。使用水杨酸偶氮哒嗪获得了更好的效果。对新型抗风湿磺胺类药物的耐受性相当令人满意；未观察到严重的副作用。这两种药物都扩展了长效抗类风湿治疗的潜力，值得进一步使用和研究。
