Perrier P, Thomas J L, Bonaiti-Pellie C, Gay G, Leclere J, Streiff F
Tissue Antigens. 1987 Jan;29(1):13-7. doi: 10.1111/j.1399-0039.1987.tb01543.x.
In this study, linkage between HLA and a dominant gene determining multiple endocrine neoplasia type 2 (MEN 2) in a large pedigree was investigated. All lod scores for recombination fractions ranging from 0 to 0.45 were negative. If we pool data from our family and the families studied by Jackson et al. (1976) and Simpson & Falk (1982), a link between HLA and the locus for MEN 2 can be excluded. Linkage studies with various markers and pooled data should be pursued to permit detection of high risk individuals and to identify a genetic defect.
在本研究中，我们对一个大家族中HLA与决定2型多发性内分泌腺瘤（MEN 2）的显性基因之间的连锁关系进行了调查。重组率在0至0.45之间的所有连锁值均为阴性。如果我们将我们家族的数据与Jackson等人（1976年）以及Simpson和Falk（1982年）研究的家族数据合并，那么HLA与MEN 2基因座之间的联系可以被排除。应继续使用各种标记进行连锁研究并合并数据，以便检测高危个体并识别遗传缺陷。
