Raffoux C, Demenais F, Dupré N, Feingold N, Streiff F
Tissue Antigens. 1983 Nov;22(5):354-8. doi: 10.1111/j.1399-0039.1983.tb02265.x.
Linkage was investigated between a dominant gene determining familial polyposis coli (FPC) and HLA in a large pedigree. A tight linkage was excluded at a value of the recombination fraction between 0 and 5%. Linkage studies with various markers should be pursued to permit detection of high risk individuals and to better understand the phenotypic variability observed in certain polyposis families.
在一个大型家系中，对决定家族性结肠息肉病（FPC）的显性基因与HLA之间的连锁关系进行了研究。在重组率介于0至5%的情况下，排除了紧密连锁。应开展与各种标记的连锁研究，以便能够检测出高危个体，并更好地理解在某些息肉病家族中观察到的表型变异性。
