Dipartimento di Bioscienze, Universita' degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy.
IFOM, The FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy.
Semin Cell Dev Biol. 2018 Feb;74:29-39. doi: 10.1016/j.semcdb.2017.08.038. Epub 2017 Aug 25.
ESCRT (Endosomal Sorting Complex Required for Transport) proteins have been shown to control an increasing number of membrane-associated processes. Some of these, and prominently regulation of receptor trafficking, profoundly shape signal transduction. Evidence in fungi, plants and multiple animal models support the emerging concept that ESCRTs are main actors in coordination of signaling with the changes in cells and tissues occurring during development and homeostasis. Consistent with their pleiotropic function, ESCRTs are regulated in multiple ways to tailor signaling to developmental and homeostatic needs. ESCRT activity is crucial to correct execution of developmental programs, especially at key transitions, allowing eukaryotes to thrive and preventing appearance of congenital defects.
ESCRT（内体分选复合物必需的运输）蛋白已被证明可以控制越来越多的与膜相关的过程。其中一些过程，特别是受体运输的调节，深刻地影响了信号转导。真菌、植物和多种动物模型的证据支持了一个新兴的概念，即 ESCRTs 是协调信号转导与发育和稳态过程中细胞和组织变化的主要因素。与它们的多功能功能一致，ESCRTs 受到多种方式的调节，以适应发育和稳态需求的信号转导。ESCRT 活性对于正确执行发育程序至关重要，特别是在关键转换时，使真核生物能够茁壮成长，并防止先天性缺陷的出现。
