Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences, South China Normal University (SCNU), Guangzhou 510631, China; These authors contributed equally to this work.
Centre for Cell and Developmental Biology, State Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong Kong (CUHK), Shatin, New Territories, Hong Kong, China; These authors contributed equally to this work.
Trends Plant Sci. 2017 Nov;22(11):986-998. doi: 10.1016/j.tplants.2017.08.003. Epub 2017 Aug 31.
The endosomal sorting complex required for transport (ESCRT) machinery is an ancient system that deforms membrane and severs membrane necks from the inside. Extensive evidence has accumulated to demonstrate the conserved functions of plant ESCRTs in multivesicular body (MVB) biogenesis and MVB-mediated membrane protein sorting. In addition, recent exciting findings have uncovered unique plant ESCRT components and point to emerging roles for plant ESCRTs in non-endosomal sorting events such as autophagy, cytokinesis, and viral replication. Plant-specific processes, such as abscisic acid (ABA) signaling and chloroplast turnover, provide further evidence for divergences in the functions of plant ESCRTs during evolution. We summarize the multiple roles and current working models for plant ESCRT machinery and speculate on future ESCRT studies in the plant field.
内体分选复合物需要运输 (ESCRT) 机制是一种古老的系统，它从内部使膜变形并切断膜颈。大量证据表明，植物 ESCRTs 在多泡体 (MVB) 生物发生和 MVB 介导的膜蛋白分选中具有保守功能。此外，最近令人兴奋的发现揭示了独特的植物 ESCRT 成分，并指出植物 ESCRTs 在自噬、胞质分裂和病毒复制等非内体分选事件中的新兴作用。植物特有的过程，如脱落酸 (ABA) 信号和叶绿体周转，为植物 ESCRTs 在进化过程中功能的分歧提供了进一步的证据。我们总结了植物 ESCRT 机制的多种作用和当前工作模型，并推测植物领域未来的 ESCRT 研究。
