Department of Wood Processing, Mendel University in Brno, Brno, Czech Republic.
Department of Pharmaceutics, Jamia Hamdard, New Delhi, India.
Drug Discov Today. 2017 Dec;22(12):1825-1834. doi: 10.1016/j.drudis.2017.08.006. Epub 2017 Aug 25.
Zinc oxide (ZnO) nanoparticles (NPs) are a promising platform for use in biomedical research, especially given their anticancer and antimicrobial activities. These activities are associated with the ability of ZnO NPs to generate reactive oxygen species (ROS) and induce apoptosis. In addition, ZnO NPs have been successfully exploited as drug carriers for loading and transporting drugs to target sites, thereby reducing unwanted toxicity and off-target effects, and resulting in amplified synergistic effects. Here, we discuss the synthesis and biomedical applications of ZnO NPs.
氧化锌 (ZnO) 纳米粒子 (NPs) 是一种很有前途的生物医学研究平台，特别是鉴于它们的抗癌和抗菌活性。这些活性与 ZnO NPs 生成活性氧物种 (ROS) 和诱导细胞凋亡的能力有关。此外，ZnO NPs 已成功地被开发为药物载体，用于将药物装载和输送到靶位，从而降低不必要的毒性和脱靶效应，并产生放大的协同效应。在这里，我们讨论了 ZnO NPs 的合成和生物医学应用。
