Kelly Darren, Raimondi Francesca, Shihab Nadia
Department of Internal Medicine, Southern Counties Veterinary Specialists LLP, Ringwood, UK.
Department of Neurology and Neurosurgery, Southern Counties Veterinary Specialists LLP, Ringwood, UK.
Vet Rec. 2017 Oct 14;181(15):401. doi: 10.1136/vr.104190. Epub 2017 Aug 28.
To evaluate the efficacy and tolerability of levetiracetam monotherapy in dogs with structural epilepsy. Retrospective case series. Nineteen client-owned dogs with structural epilepsy. Seizure frequencies after initiation of treatment were used to evaluate the efficacy of levetiracetam monotherapy. Seizure control was considered good if no seizures occurred within three months of starting treatment or poor if seizures returned within one month of starting treatment. Tolerability was evaluated by considering the occurrence and severity of any reported side effects. Ten of the 19 dogs were considered to have a good response to treatment with 7 achieving complete seizure freedom. Nine dogs were considered to have poor response to treatment. There was a statistically significant reduction in the percentage of patients experiencing cluster seizures from 68.4% to 15.8% (p=0.002). Side effects were noted in 8 of the 19 dogs but were considered mild in all cases. Follow-up times ranged from 12 days to 426 days. When used in conjunction with other appropriate therapies, levetiracetam may be an efficacious option for monotherapy in dogs with structural epilepsy. Its tolerability makes it a suitable option for use in a wide variety of patients.
评估左乙拉西坦单药治疗结构性癫痫犬的疗效和耐受性。回顾性病例系列研究。19只客户拥有的结构性癫痫犬。治疗开始后的癫痫发作频率用于评估左乙拉西坦单药治疗的疗效。如果在开始治疗后三个月内未发生癫痫发作，则认为癫痫控制良好；如果在开始治疗后一个月内癫痫复发，则认为控制不佳。通过考虑任何报告的副作用的发生情况和严重程度来评估耐受性。19只犬中有10只被认为对治疗反应良好，其中7只实现了完全无癫痫发作。9只犬被认为对治疗反应不佳。经历丛集性癫痫发作的患者百分比从68.4%显著降低至15.8%（p = 0.002）。19只犬中有8只出现了副作用，但所有病例均被认为是轻度的。随访时间从12天到426天不等。当与其他适当的治疗方法联合使用时，左乙拉西坦可能是结构性癫痫犬单药治疗的有效选择。其耐受性使其成为适用于各种患者的合适选择。
