Volk Holger A, Matiasek Lara A, Luján Feliu-Pascual Alejandro, Platt Simon R, Chandler Kate E
Department of Veterinary Clinical Sciences, Neurology, Royal Veterinary College, Hatfield, UK.
Vet J. 2008 Jun;176(3):310-9. doi: 10.1016/j.tvjl.2007.03.002. Epub 2007 Apr 30.
Twenty-two dogs with idiopathic epilepsy which were pharmacoresistant to phenobarbitone and bromide were treated with levetiracetam as an add-on medication. Records of eight dogs were used retrospectively to determine a safe, efficient levetiracetam dosage. Fourteen dogs were entered into a prospective, open label, non-comparative study. After 2 months of levetiracetam oral treatment (10 mg/kg TID), 8/14 dogs responded significantly to the treatment and seizure frequency was reduced by 50%. In dogs that remained refractory, the dosage was increased to 20 mg/kg TID for 2 months. One further dog responded to levetiracetam treatment. Levetiracetam responders had a significant decrease in seizure frequency of 77% (7.9+/-5.2 to 1.8+/-1.7 seizures/month) and a decrease in seizure days per month of 68% (3.8+/-1.7 to 1.2+/-1.1 seizure days/month). However, 6/9 responders experienced an increase in seizure frequency and seizure days after 4-8 months continuing with the levetiracetam treatment at the last effective dosage. Levetiracetam was well tolerated by all dogs and sedation was the only side-effect reported in just one of the 14 dogs.
22只对苯巴比妥和溴化物耐药的特发性癫痫犬接受了左乙拉西坦作为附加药物的治疗。回顾性分析了8只犬的记录，以确定安全有效的左乙拉西坦剂量。14只犬进入了一项前瞻性、开放标签、非对照研究。在左乙拉西坦口服治疗2个月（10mg/kg，每日3次）后，14只犬中有8只对治疗有显著反应，癫痫发作频率降低了50%。对于仍难治的犬，剂量增加到20mg/kg，每日3次，持续2个月。又有1只犬对左乙拉西坦治疗有反应。左乙拉西坦治疗有反应的犬癫痫发作频率显著降低77%（从7.9±5.2次/月降至1.8±1.7次/月），每月癫痫发作天数减少68%（从3.8±1.7天/月降至1.2±1.1天/月）。然而，9只治疗有反应的犬中有6只在以最后有效剂量继续左乙拉西坦治疗4-8个月后癫痫发作频率和发作天数增加。所有犬对左乙拉西坦耐受性良好，14只犬中只有1只报告有镇静这一副作用。
