Department of Neurology & Neurosurgery, Montréal Neurological Institute, McGill University, Montréal, Quebec H3A 2B4, Canada.
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064.
Cold Spring Harb Perspect Biol. 2018 Nov 1;10(11):a029165. doi: 10.1101/cshperspect.a029165.
The field of axon guidance was revolutionized over the past three decades by the identification of highly conserved families of guidance cues and receptors. These proteins are essential for normal neural development and function, directing cell and axon migration, neuron-glial interactions, and synapse formation and plasticity. Many of these genes are also expressed outside the nervous system in which they influence cell migration, adhesion and proliferation. Because the nervous system develops from neural epithelium, it is perhaps not surprising that these guidance cues have significant nonneural roles in governing the specialized junctional connections between cells in polarized epithelia. The following review addresses roles for ephrins, semaphorins, netrins, slits and their receptors in regulating adherens, tight, and gap junctions in nonneural epithelia and endothelia.
过去三十年中，通过鉴定高度保守的导向线索和受体家族，轴突导向领域发生了革命性变化。这些蛋白质对于正常的神经发育和功能至关重要，它们指导细胞和轴突迁移、神经元-神经胶质相互作用以及突触形成和可塑性。许多这些基因在神经系统外也有表达，它们影响细胞迁移、黏附和增殖。由于神经系统是由神经上皮发育而来的，因此这些导向线索在调节极化上皮细胞之间的特殊连接连接中具有重要的非神经作用，这也许并不奇怪。以下综述介绍了 Ephrins、Semaphorins、Netrins、Slits 及其受体在调节非神经上皮和内皮细胞的黏附连接、紧密连接和缝隙连接中的作用。
