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Is It Time to Reconsider the Lipopolysaccharide Paradigm in Acute Graft-Versus-Host Disease?

作者信息

Daguindau Etienne, Gautier Thomas, Chagué Cécile, Pais de Barros Jean-Paul, Deckert Valérie, Lagrost Laurent, Saas Philippe

机构信息

Université Bourgogne Franche-Comté, EFS Bourgogne Franche-Comté, INSERM, UMR1098, Besançon, France.

Department of Hematology, University Hospital of Besançon, Besançon, France.

出版信息

Front Immunol. 2017 Aug 9;8:952. doi: 10.3389/fimmu.2017.00952. eCollection 2017.

DOI:10.3389/fimmu.2017.00952
PMID:28848554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5553011/
Abstract
摘要

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本文引用的文献

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Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis.重组人血浆磷脂转移蛋白(PLTP)预防细菌生长和治疗败血症。
Sci Rep. 2017 Jun 8;7(1):3053. doi: 10.1038/s41598-017-03285-9.
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Mining the Human Gut Microbiota for Immunomodulatory Organisms.挖掘人类肠道微生物群中的免疫调节微生物。
Cell. 2017 Feb 23;168(5):928-943.e11. doi: 10.1016/j.cell.2017.01.022. Epub 2017 Feb 16.
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Repeated fecal microbiota transplantations attenuate diarrhea and lead to sustained changes in the fecal microbiota in acute, refractory gastrointestinal graft--host-disease.反复进行粪便微生物群移植可减轻急性难治性胃肠道移植物抗宿主病中的腹泻,并导致粪便微生物群的持续变化。
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Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein.肝脏窦状内皮细胞通过高密度脂蛋白快速清除血源性脂多糖。
J Immunol. 2016 Sep 15;197(6):2390-9. doi: 10.4049/jimmunol.1600702. Epub 2016 Aug 17.
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Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut.粪便微生物群移植用于肠道类固醇难治性急性移植物抗宿主病患者。
Blood. 2016 Oct 20;128(16):2083-2088. doi: 10.1182/blood-2016-05-717652. Epub 2016 Jul 26.
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Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.在人类患者和小鼠接受异基因造血干细胞移植后,使用广谱抗生素会增加移植物抗宿主病(GVHD)相关死亡率。
Sci Transl Med. 2016 May 18;8(339):339ra71. doi: 10.1126/scitranslmed.aaf2311.
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Structure and function: Lipid A modifications in commensals and pathogens.结构与功能:共生菌和病原体中的脂质A修饰
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Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease.肠道微生物群衍生的代谢产物可调节肠道上皮细胞损伤并减轻移植物抗宿主病。
Nat Immunol. 2016 May;17(5):505-513. doi: 10.1038/ni.3400. Epub 2016 Mar 21.
10
Decreased secretion of Paneth cell α-defensins in graft-versus-host disease.移植物抗宿主病中潘氏细胞α-防御素分泌减少。
Transpl Infect Dis. 2015 Oct;17(5):702-6. doi: 10.1111/tid.12423. Epub 2015 Sep 26.