Kanat Ozkan, Ertas Hulya, Caner Burcu
Ozkan Kanat, Hulya Ertas, Burcu Caner, Department of Medical Oncology, Uludag University Faculty of Medicine, 16059 Bursa, Turkey.
World J Clin Oncol. 2017 Aug 10;8(4):329-335. doi: 10.5306/wjco.v8.i4.329.
Patients treated with platinum-based chemotherapy frequently experience neurotoxic symptoms, which may lead to premature discontinuation of therapy. Despite discontinuation of platinum drugs, these symptoms can persist over a long period of time. Cisplatin and oxaliplatin, among all platinum drugs, have significant neurotoxic potential. A distal dose-dependent symmetrical sensory neuropathy is the most common presentation of platinum neurotoxicity. DNA damage-induced apoptosis of dorsal root ganglion (DRG) neurons seems to be the principal cause of neurological symptoms. However, DRG injury alone cannot explain some unique symptoms such as cold-aggravated burning pain affecting distal extremities that is observed with oxaliplatin administration. In this article, we briefly reviewed potential mechanisms for the development of platinum drugs-associated neurological manifestations.
接受铂类化疗的患者经常出现神经毒性症状，这可能导致治疗提前中断。尽管停用了铂类药物，但这些症状可能会长期持续。在所有铂类药物中，顺铂和奥沙利铂具有显著的神经毒性潜力。远端剂量依赖性对称性感觉神经病变是铂类神经毒性最常见的表现形式。DNA损伤诱导的背根神经节（DRG）神经元凋亡似乎是神经症状的主要原因。然而，仅DRG损伤并不能解释一些独特的症状，如奥沙利铂给药时观察到的影响远端肢体的冷加重灼痛。在本文中，我们简要回顾了铂类药物相关神经表现发生的潜在机制。
