Schnabel T
Am J Med. 1987 May 22;82(5A):7-13. doi: 10.1016/0002-9343(87)90197-5.
Historically, the use of anxiolytic drugs has been associated with a relatively high incidence of side effects, particularly those related to central nervous system depression and sedation. These side effects can impair the patient's ability to function and, thus, interfere with the full achievement of therapeutic goals. In this article, the evolution of anxiolytic drug therapy from the perspective of safety and side effects is reviewed. Moreover, data concerning the safety of buspirone--a novel, non-benzodiazepine anxiolytic that has been shown to provide anxiolytic efficacy comparable to that of the benzodiazepines, but with a significantly lower potential for central nervous system depressant effects, interactions with alcohol, dependence, and abuse--are discussed.
从历史上看，抗焦虑药物的使用一直与相对较高的副作用发生率相关，尤其是那些与中枢神经系统抑制和镇静有关的副作用。这些副作用会损害患者的功能能力，从而干扰治疗目标的完全实现。本文从安全性和副作用的角度回顾了抗焦虑药物治疗的演变。此外，还讨论了有关丁螺环酮安全性的数据，丁螺环酮是一种新型非苯二氮䓬类抗焦虑药物，已被证明具有与苯二氮䓬类药物相当的抗焦虑疗效，但具有中枢神经系统抑制作用、与酒精相互作用、成瘾和滥用的可能性显著更低。
