肺气肿的病理生理学及影响
Pathophysiology of Emphysema and Implications.
作者信息
Goldklang Monica, Stockley Robert
机构信息
Departments of Anesthesiology and Medicine, Columbia University Medical Center, New York, New York.
Department of Medicine, Queen Elizabeth Hospital, Birmingham, United Kingdom.
出版信息
Chronic Obstr Pulm Dis. 2016 Jan 15;3(1):454-458. doi: 10.15326/jcopdf.3.1.2015.0175.
Abstract
This article serves as a CME-available, enduring material summary of the following COPD9 presentations: "Overview of Lung Injury in COPD: Types and Key Questions" Caroline Owen, MD, PhD Emphysema as a Disease of Deficient Tissue Repair/Maintenance" : Rubin Tuder, MD.
摘要
本文是以下慢性阻塞性肺疾病（COPD）相关报告的可用于继续医学教育（CME）的永久性材料总结：“COPD 中的肺损伤概述：类型及关键问题”，卡罗琳·欧文医学博士、哲学博士；“作为组织修复/维持不足疾病的肺气肿”，鲁宾·图德医学博士。
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2
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3
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Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1149-57. doi: 10.1152/ajplung.00481.2007. Epub 2008 Apr 11.
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