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肺气肿的病理生理学及影响

Pathophysiology of Emphysema and Implications.

作者信息

Goldklang Monica, Stockley Robert

机构信息

Departments of Anesthesiology and Medicine, Columbia University Medical Center, New York, New York.

Department of Medicine, Queen Elizabeth Hospital, Birmingham, United Kingdom.

出版信息

Chronic Obstr Pulm Dis. 2016 Jan 15;3(1):454-458. doi: 10.15326/jcopdf.3.1.2015.0175.

DOI:10.15326/jcopdf.3.1.2015.0175
PMID:28848866
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5559126/
Abstract

This article serves as a CME-available, enduring material summary of the following COPD9 presentations: "Overview of Lung Injury in COPD: Types and Key Questions" Caroline Owen, MD, PhD Emphysema as a Disease of Deficient Tissue Repair/Maintenance" : Rubin Tuder, MD.

摘要

本文是以下慢性阻塞性肺疾病（COPD）相关报告的可用于继续医学教育（CME）的永久性材料总结：“COPD 中的肺损伤概述：类型及关键问题”，卡罗琳·欧文医学博士、哲学博士；“作为组织修复/维持不足疾病的肺气肿”，鲁宾·图德医学博士。

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本文引用的文献

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Reply: the lung immune response to bacteria in chronic obstructive pulmonary disease.回复：慢性阻塞性肺疾病中肺部对细菌的免疫反应
Am J Respir Crit Care Med. 2015 Oct 1;192(7):903-4. doi: 10.1164/rccm.201506-1257LE.
2
B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease.B细胞活化因子。重度慢性阻塞性肺疾病中淋巴滤泡的协调者。
Am J Respir Crit Care Med. 2015 Sep 15;192(6):695-705. doi: 10.1164/rccm.201501-0107OC.
3
RTP801 is required for ceramide-induced cell-specific death in the murine lung.RTP801 对于鞘氨醇诱导的小鼠肺部细胞特异性死亡是必需的。
Am J Respir Cell Mol Biol. 2013 Jan;48(1):87-93. doi: 10.1165/rcmb.2012-0254OC. Epub 2012 Sep 28.
4
Telomere length is a determinant of emphysema susceptibility.端粒长度是肺气肿易感性的决定因素。
Am J Respir Crit Care Med. 2011 Oct 15;184(8):904-12. doi: 10.1164/rccm.201103-0520OC. Epub 2011 Jul 14.
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Inhibition of histone deacetylase causes emphysema.组蛋白去乙酰化酶抑制可导致肺气肿。
Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L402-13. doi: 10.1152/ajplung.00207.2010. Epub 2010 Dec 17.
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Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema.自噬蛋白微管相关蛋白 1 轻链 3B（LC3B）在香烟烟雾诱导的肺气肿中外在凋亡中激活。
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18880-5. doi: 10.1073/pnas.1005574107. Epub 2010 Oct 18.
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Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice.基质金属蛋白酶-8 使巨噬细胞炎性蛋白-1α失活，从而减轻小鼠的急性肺炎症和损伤。
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Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin.基质金属蛋白酶-9的转基因表达导致小鼠成年后发生肺气肿，并伴有肺泡弹性蛋白的丧失。
Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1149-57. doi: 10.1152/ajplung.00481.2007. Epub 2008 Apr 11.
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