Mai Shaoyu, Rao Changqing, Chen Ming, Su Jihu, Du Jiangfeng, Song Qiuling
Institute of Next Generation Matter Transformation, College of Chemical Engineering, College of Material Sciences, Huaqiao University, Xiamen, Fujian 361021, China.
CAS Key Laboratory of Microscale Magnetic Resonance, Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026, China.
Chem Commun (Camb). 2017 Sep 19;53(75):10366-10369. doi: 10.1039/c7cc05746f.
Novel catalytic systems consisting of cationic gold complexes, N-hydroxyphthalimide (NHPI), and transition-metal-based Lewis acids have been developed for the one-pot synthesis of functionalized oxazoles from N-propargylamides with excellent functional group tolerance. These transformations demonstrated the excellent compatibility of homogeneous gold catalysis with organocatalytic oxidative carbon-nitrogen bond formations using tert-butyl nitrite as the terminal oxidant. Moreover, oxazolecarbonitriles or carboxamides can be easily synthesized in a one-pot protocol according to the different synthetic requirements.
由阳离子金配合物、N-羟基邻苯二甲酰亚胺(NHPI)和过渡金属基路易斯酸组成的新型催化体系已被开发用于从N-炔丙基酰胺一锅法合成功能化恶唑,具有出色的官能团耐受性。这些转化证明了均相金催化与使用亚硝酸叔丁酯作为终端氧化剂的有机催化氧化碳-氮键形成具有出色的兼容性。此外,根据不同的合成要求,可以通过一锅法轻松合成恶唑腈或羧酰胺。