性别和 HIV 血清状态对可卡因使用者空间导航学习和记忆的影响。
Effects of sex and HIV serostatus on spatial navigational learning and memory among cocaine users.
机构信息
Department of Psychology, University of Illinois at Chicago, Chicago, IL, USA.
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
出版信息
J Neurovirol. 2017 Dec;23(6):855-863. doi: 10.1007/s13365-017-0563-7. Epub 2017 Aug 28.
Abstract
Spatial learning and memory are critically dependent on the integrity of hippocampal systems. Functional MRI and neuropathological studies show that hippocampal circuitry is prominently affected among HIV-seropositive individuals, but potential spatial learning and memory deficits have not been studied in detail in this population. We investigated the independent and interactive effects of sex and HIV serostatus on performance of a spatial learning and memory task in a sample of 181 individuals with a history of cocaine dependence. We found that men showed faster times to completion on immediate recall trials compared with women and that delayed recall was significantly poorer among HIV-infected compared with HIV-uninfected participants. Additionally, a sex × serostatus effect was found on the total number of completed learning trials. Specifically, HIV-infected men successfully completed more learning trials compared with HIV-infected women. Results are discussed in the context of recent reports of sex and HIV serostatus effects on episodic memory performance.
摘要
空间学习和记忆能力严重依赖海马系统的完整性。功能磁共振成像和神经病理学研究表明，在 HIV 阳性个体中，海马回路受到明显影响，但在该人群中尚未详细研究潜在的空间学习和记忆缺陷。我们在一组有可卡因依赖史的 181 名个体中研究了性别和 HIV 血清阳性状态对空间学习和记忆任务表现的独立和交互影响。我们发现，男性在即时回忆试验中完成的时间比女性更快，而与 HIV 未感染者相比，HIV 感染者的延迟回忆明显更差。此外，在完成学习试验的总数上发现了性别与血清阳性状态的相互作用。具体来说，与 HIV 感染的女性相比，HIV 感染的男性成功完成了更多的学习试验。研究结果在最近关于性别和 HIV 血清阳性状态对情景记忆表现的影响的报告背景下进行了讨论。
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