Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Department of Veterans Affairs, VA North Texas Health Care System, Dallas, TX, USA.
Ann Surg Oncol. 2017 Nov;24(12):3725-3731. doi: 10.1245/s10434-017-6062-5. Epub 2017 Aug 28.
Data on the risk factors for conversion during minimally invasive distal pancreatectomy (MIDP) and its effect on postoperative outcomes are limited.
This retrospective study used the pancreas-targeted American College of Surgeons National Surgical Quality Improvement Program database to compare MIDP requiring unplanned conversion with completed MIDP and open distal pancreatectomy (ODP).
Of the 2926 cases identified in this study, 48.8% had ODP, 42.8% had MIDP, and 7.9% had conversion to MIDP. The conversion rate was 15.3% overall, 17.3% for laparoscopic surgery, and 8.5% for robotic surgery (p < 0.001). The risk factors associated with conversion were higher body mass index (BMI), low preoperative albumin level, a current smoking habit, and malignant T3/T4 disease or chronic pancreatitis compared with benign tumor smaller than 5 cm. A robotic approach was associated with a lower adjusted conversion rate than laparoscopy (odds ratio [OR] 0.32; 95% confidence interval [CI] 0.19-0.52). After adjustment, conversion was associated with a higher overall complication rate than MIDP (OR 1.89; 95% CI 1.35-2.66) or ODP (OR 1.41; 95% CI 1.00-1.98).
Chronic pancreatitis, large malignant tumors, higher BMI, lower serum albumin, and a current smoking habit were shown to be independent risk factors for conversion during MIDP. A robotic approach was associated with a lower conversion rate than laparoscopic MIDP. Conversion of MIDP was associated with a higher overall complication rate than completed MIDP or ODP. Adequate patient selection for MIDP may prevent conversion and associated increased morbidity.
微创远端胰腺切除术(MIDP)中转开腹的风险因素及其对术后结局的影响的数据有限。
本回顾性研究使用美国外科医师学院国家外科质量改进计划胰腺靶向数据库,比较需要计划外中转的 MIDP 与完成的 MIDP 和开放远端胰腺切除术(ODP)。
在这项研究中,确定了 2926 例患者,其中 48.8%为 ODP,42.8%为 MIDP,7.9%中转为 MIDP。总体中转率为 15.3%,腹腔镜手术为 17.3%,机器人手术为 8.5%(p<0.001)。与良性肿瘤<5cm 相比,与中转相关的危险因素包括较高的体重指数(BMI)、术前低白蛋白水平、当前吸烟习惯以及恶性 T3/T4 疾病或慢性胰腺炎。与腹腔镜相比,机器人方法与较低的调整后中转率相关(比值比[OR]0.32;95%置信区间[CI]0.19-0.52)。调整后,与 MIDP(OR 1.89;95%CI 1.35-2.66)或 ODP(OR 1.41;95%CI 1.00-1.98)相比,中转与更高的总体并发症发生率相关。
慢性胰腺炎、大的恶性肿瘤、较高的 BMI、较低的血清白蛋白和当前吸烟习惯被证明是 MIDP 中转的独立危险因素。与腹腔镜 MIDP 相比,机器人方法与较低的中转率相关。与完成的 MIDP 或 ODP 相比,MIDP 的中转与更高的总体并发症发生率相关。对 MIDP 进行充分的患者选择可能会预防中转和相关的发病率增加。