Stiles Zachary E, Dickson Paxton V, Deneve Jeremiah L, Glazer Evan S, Dong Lei, Wan Jim Y, Behrman Stephen W
Division of Surgical Oncology, Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee.
Division of Biostatistics, Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
J Surg Res. 2018 Jul;227:168-177. doi: 10.1016/j.jss.2018.02.028. Epub 2018 Mar 19.
Minimally invasive pancreatic resection (MIPR) is being increasingly utilized. Outcomes for patients experiencing unplanned conversion to an open procedure during MIPR have been incompletely assessed. We sought to determine the short-term outcomes and factors associated with unplanned conversion during MIPR.
A retrospective cohort study using the American College of Surgeons National Surgical Quality Improvement Program pancreatectomy-targeted data set was conducted. Successful MIPR was compared with unplanned conversion. Propensity matching was used to separately compare unplanned conversion during MIPR with planned open pancreatectomy.
Unplanned conversion occurred in 24.6% of 350 attempted minimally invasive pancreatoduodenectomy (MIPD) and 19.6% of 1174 attempted minimally invasive distal pancreatectomy (MIDP). Conversion was associated with greater overall morbidity and 30-day mortality compared with successful MIPR for both MIPD and MIDP. After matching, unplanned conversion resulted in outcomes equivalent or inferior to open pancreatectomy. Factors significantly associated with unplanned conversion during MIPD included intermediate gland texture, vascular resection, hypertension, disseminated cancer, and chronic steroid use. For MIDP, male sex, hard gland texture, vascular resection, smoking, and recent weight loss were independently associated with conversion. A robotic approach was inversely associated with conversion for MIPD and MIDP.
Unplanned conversion during MIPR is associated with greater morbidity and 30-day mortality. Conversion resulted in outcomes that, at best, mimicked those of open pancreatectomy. Several risk factors including the need for vascular resection are associated with unplanned conversion and should be acknowledged when planning an operative approach.
微创胰腺切除术(MIPR)的应用越来越广泛。对于在MIPR过程中意外转为开放手术的患者,其预后尚未得到充分评估。我们试图确定MIPR期间的短期预后以及与意外转为开放手术相关的因素。
采用美国外科医师学会国家外科质量改进计划中针对胰腺切除术的数据集进行回顾性队列研究。将成功的MIPR与意外转为开放手术的情况进行比较。使用倾向匹配法分别将MIPR期间的意外转为开放手术与计划性开放胰腺切除术进行比较。
在350例尝试的微创胰十二指肠切除术(MIPD)中,24.6%发生了意外转为开放手术;在1174例尝试的微创远端胰腺切除术(MIDP)中,19.6%发生了意外转为开放手术。与成功的MIPR相比,MIPD和MIDP转为开放手术均与更高的总体发病率和30天死亡率相关。匹配后,意外转为开放手术的预后等同于或差于开放胰腺切除术。与MIPD期间意外转为开放手术显著相关的因素包括胰腺质地中等、血管切除、高血压、播散性癌和长期使用类固醇。对于MIDP,男性、胰腺质地硬、血管切除、吸烟和近期体重减轻与转为开放手术独立相关。机器人手术方式与MIPD和MIDP的转为开放手术呈负相关。
MIPR期间的意外转为开放手术与更高的发病率和30天死亡率相关。转为开放手术的预后充其量与开放胰腺切除术相似。包括血管切除需求在内的几个危险因素与意外转为开放手术相关,在规划手术方式时应予以考虑。