一项关于学龄儿童同型半胱氨酸及其与体重指数和血脂谱关系的前瞻性研究。

A Prospective Study of Homocysteine and its relation to Body Mass Index and Lipid Profile in School Children.

作者信息

Kumar K Jagadish, Saldanha Karen, Sushma K, Murthy D Srinivasa, Vishwanath Prashanth

机构信息

Departments of Pediatrics and *Biochemistry, JSS Medical College, JSS University, Mysore, Karnataka, India. Correspondence to: Dr K Jagadish Kumar, 85/B, 9th Cross, Navilu Road, Kuvempu Nagar, Mysore, Karnataka 570 023, India.

出版信息

Indian Pediatr. 2017 Nov 15;54(11):935-937. doi: 10.1007/s13312-017-1185-0. Epub 2017 Aug 24.

DOI:10.1007/s13312-017-1185-0

PMID:28849772

Abstract

OBJECTIVE

To study the serum Homocysteine levels in children and its relation with body mass index (BMI), lipid profile and plasma glucose.

METHODS

138 children (age 5-15 y) were enrolled and categorized into normal, overweight and obese group. Blood homocysteine, lipid profile and plasma glucose were estimated.

RESULTS

Out of 138 children, 46 (33%) were normal, 40 (29%) were overweight and 52 (38%) were obese. Hyper-homocysteinemia was found in 34 (24.6%) of children. None of the normal children had hyperhomocysteinemia in contrast to 15 (37.5%) in overweight and 19 (36.5%) in obese group (P=0.001).The median homocysteine levels in obese and overweight children was significantly higher compared to normal children (P=0.001).There was a positive correlation between BMI and homocysteine levels. There was no significant correlation between lipid profile and plasma glucose with homocysteine levels.

CONCLUSION

Serum homocysteine levels are significantly higher in both overweight and obese children compared to normal children.

摘要

目的

研究儿童血清同型半胱氨酸水平及其与体重指数（BMI）、血脂谱和血糖的关系。

方法

纳入138名5至15岁儿童，分为正常、超重和肥胖组。检测血同型半胱氨酸、血脂谱和血糖。

结果

138名儿童中，46名（33%）正常，40名（29%）超重，52名（38%）肥胖。34名（24.6%）儿童存在高同型半胱氨酸血症。正常儿童中无高同型半胱氨酸血症，超重组有15名（37.5%），肥胖组有19名（36.5%）（P = 0.001）。肥胖和超重儿童的同型半胱氨酸水平中位数显著高于正常儿童（P = 0.001）。BMI与同型半胱氨酸水平呈正相关。血脂谱和血糖与同型半胱氨酸水平无显著相关性。