Åkerblom Hans K, Viikari Jorma, Raitakari Olli T, Uhari Matti
a Hospital for Children and Adolescents, University of Helsinki , Helsinki , Finland.
b Department of Medicine , University of Turku , Turku , Finland.
Ann Med. 1999;31(sup1):45-54. doi: 10.1080/07853890.1999.11904399.
The Cardiovascular Risk in Young Finns Study is a collaborative effort of all university departments of paediatrics and several other institutions in Finland to study the risk factors of coronary heart disease (CHD) and their determinants in children and adolescents in different parts of the country. The main cross-sectional study carried out in 1980 included 3596 3-18-year-old subjects. Follow-up studies have been performed in 1983, 1986, 1989 and 1992; in the last of these studies the subjects were 15-30 years old. The findings in anthropometry, obesity and blood pressure have been rather similar to reports from other countries in Europe. However, serum cholesterol and low-density lipoprotein cholesterol concentrations were higher than in other countries, 4.83 mmol/L and 3.09 mmol/L, respectively in 1980. By 1992 a decrease of 8% took place, probably as a result of dietary changes. Apolipoprotein phenotypes E4E4 or E4E3 were relatively frequent (34%) in the sample. Tracking and clustering have also been studied. Serum insulin levels predicted the clustering of the typical risk factor profile associated with insulin resistance syndrome. The dietary polyunsaturated to saturated fat (P/S) ratio increased from 0.26 in 1980 to 0.39 in 1992, with no significant changes in the total energy derived from fat. 'Hard-driving' was found to be the psychological risk factor most consistently related to the CHD risk factor level.
芬兰青年人心血管风险研究是芬兰所有大学儿科系与其他几个机构的一项合作项目，旨在研究该国不同地区儿童和青少年冠心病（CHD）的危险因素及其决定因素。1980年进行的主要横断面研究纳入了3596名3至18岁的受试者。后续研究分别于1983年、1986年、1989年和1992年开展；在最后一项研究中，受试者年龄为15至30岁。人体测量学、肥胖和血压方面的研究结果与欧洲其他国家的报告颇为相似。然而，血清胆固醇和低密度脂蛋白胆固醇浓度高于其他国家，1980年分别为4.83 mmol/L和3.09 mmol/L。到1992年，这一数值下降了8%，可能是饮食变化所致。载脂蛋白E4E4或E4E3表型在样本中相对常见（34%）。研究还涉及追踪和聚类情况。血清胰岛素水平可预测与胰岛素抵抗综合征相关的典型危险因素组合的聚类情况。饮食中多不饱和脂肪酸与饱和脂肪酸的比例（P/S）从1980年的0.26增至1992年的0.39，而脂肪提供的总能量无显著变化。研究发现，“急进型”是与冠心病危险因素水平最密切相关的心理危险因素。
