Kolesnichenko L S, Mantorova N S, Shapiro L A
Biokhimiia. 1987 May;52(5):743-9.
In vivo exo- and endogenous catecholamines have no influence on the activities of thioredoxin reductase, glutathione reductase, thiol transferase and nonselenium-dependent glutathione peroxidase. At the same time catecholamines activate via beta-adrenoceptors glutathione S-transferase and selenium-dependent glutathione peroxidase from many tissues and inhibit gamma-glutamyl transferase from kidney. In vitro cAMP has identical effects on the activities of the above enzymes. The possible significance of regulation of glutathione metabolism enzymes is discussed.
体内外源性和内源性儿茶酚胺对硫氧还蛋白还原酶、谷胱甘肽还原酶、硫醇转移酶和非硒依赖性谷胱甘肽过氧化物酶的活性均无影响。同时，儿茶酚胺通过β-肾上腺素能受体激活许多组织中的谷胱甘肽S-转移酶和硒依赖性谷胱甘肽过氧化物酶，并抑制肾脏中的γ-谷氨酰转移酶。在体外，环磷酸腺苷（cAMP）对上述酶的活性具有相同的作用。文中讨论了谷胱甘肽代谢酶调节的可能意义。
