Struve F A
Clin Electroencephalogr. 1987 Apr;18(2):46-53.
In three independent comparisons, patients treated with lithium carbonate (either alone or in combination with other agents) were contrasted with both medication free and other psychotropic medicated patients, in terms of the prevalence of abnormal generalized slowing and paroxysmal diffuse delta activity in the clinical EEG. In all samples, abnormal EEG changes occurred in from 30.3 to 39.4% of lithium treated patients as contrasted with from only 1.5 to 4.6% of medication free controls. In all comparisons, the prevalence of abnormal EEGs was significantly higher for lithium treated patients than for patients free of medication or those treated with other psychotropic agents. EEG changes are reversible with discontinuance of lithium, and their role in suggesting potential early neurotoxicity is discussed.
在三项独立比较中，将接受碳酸锂治疗（单独使用或与其他药物联合使用）的患者与未用药患者以及使用其他精神药物治疗的患者进行对比，比较临床脑电图中异常广泛性慢波和阵发性弥漫性δ活动的发生率。在所有样本中，接受锂治疗的患者中脑电图出现异常变化的比例为30.3%至39.4%，而未用药对照组中这一比例仅为1.5%至4.6%。在所有比较中，接受锂治疗的患者脑电图异常的发生率显著高于未用药患者或使用其他精神药物治疗的患者。停用锂后脑电图变化是可逆的，并对其在提示潜在早期神经毒性方面的作用进行了讨论。
