Shi Y Y, Jia R B, Fan X Q
Department of Ophthalmology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medical, Shanghai 200011, China.
Zhonghua Yan Ke Za Zhi. 2017 Aug 11;53(8):632-636. doi: 10.3760/cma.j.issn.0412-4081.2017.08.017.
Lymphoma is one of the most common malignant tumor of the orbit in adults. Orbital lymphoma mainly consists of extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue, follicular lymphoma, diffuse large B-cell lymphoma, mantle cell lymphoma, infrequent NK/T cell lymphoma and Burkitt lymphoma. Diagnosis on orbital lymphoma remains challenging in that it is difficult to distinguish it from benign lesions, especially for low degree lymphomas. Combined examinations of histological, cytological and molecular features are required to make final differentiation. There are many treatment options for diagnosis of orbital lymphoma, such as surgical resection, radiotherapy, chemotherapy, monoclonal antibody targeted therapy, immunotherapy. The appropriate scenario of treatment on orbital lymphoma should be made based on the Ann Arbor or TNM staging system to determine the stage of orbital lymphoma at the moment for maximizing the results. The latest concepts on diagnosis and management of orbital lymphoma are reviewed in this paper. -.
淋巴瘤是成人眼眶最常见的恶性肿瘤之一。眼眶淋巴瘤主要由黏膜相关淋巴组织的结外边缘区B细胞淋巴瘤、滤泡性淋巴瘤、弥漫性大B细胞淋巴瘤、套细胞淋巴瘤、罕见的NK/T细胞淋巴瘤和伯基特淋巴瘤组成。眼眶淋巴瘤的诊断仍然具有挑战性，因为很难将其与良性病变区分开来，尤其是低度淋巴瘤。需要结合组织学、细胞学和分子特征检查来进行最终鉴别。眼眶淋巴瘤的诊断有多种治疗选择，如手术切除、放疗、化疗、单克隆抗体靶向治疗、免疫治疗。眼眶淋巴瘤的适当治疗方案应根据Ann Arbor或TNM分期系统制定，以确定目前眼眶淋巴瘤的分期，从而使治疗效果最大化。本文综述了眼眶淋巴瘤诊断和治疗的最新概念。 -
