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稽留流产患者蜕膜中TIPE2蛋白表达降低及其可能的意义

The decreased expression of TIPE2 protein in the decidua of patients with missed abortion and possible significance.

作者信息

Sun Yingshuo, Wang Xiaoyan, Li Yue, Sun Han, Wan Lu, Wang Xishuang, Zhang Lining, Fang Zhenghui, Wei Zengtao

机构信息

Department of Gynecology and Obstetrics, Clinical Medical School, Shandong University, 44# Wenhua Xi Road, Jinan, Shandong, 250012, People's Republic of China.

Department of Immunology, School of Basic Medical Sciences, Shandong University, 44# Wenhua Xi Road, Jinan, Shandong, People's Republic of China.

出版信息

Reprod Biol Endocrinol. 2017 Aug 29;15(1):68. doi: 10.1186/s12958-017-0285-y.

DOI:10.1186/s12958-017-0285-y
PMID:28851386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5576376/
Abstract

BACKGROUND

Missed abortion is a common occurrence for otherwise healthy women. Immunological factor is one of the most important reasons. Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) is a novel negative immune regulator related to several human diseases. However, the expression level and clinical significance of TIPE2 in missed abortion remain unclear.

METHODS

The expression of TIPE2 mRNA and protein in decidua and chorion from 36 missed abortion patients and 36 healthy controls was detected using quantitative real-time PCR, western blot and immunohistochemistry. In addition, serum TNF-ɑ and IL-10 levels were measured using flow cytometry. Serum estradiol and progesterone levels were measured by radioimmunoassay test. The correlations of TIPE2 protein levels with TNF-ɑ, IL-10, estradiol and progesterone were further analyzed.

RESULTS

TIPE2 protein levels were significantly lower in decidual tissues of missed abortion patients than those in healthy controls. The patients with missed abortion had significantly higher levels of serum TNF-ɑ, and lower levels of serum IL-10, estradiol and progesterone compared with healthy controls. The TIPE2 protein levels were positively related to serum IL-10 levels.

CONCLUSION

Our data indicate TIPE2 could play important roles in maintaining the maternal-fetal tolerance and decreased TIPE2 expression in the decidua may be related to the development of missed abortion.

摘要

背景

稽留流产在健康女性中较为常见。免疫因素是其最重要的原因之一。肿瘤坏死因子-α诱导蛋白8样蛋白2（TIPE2）是一种与多种人类疾病相关的新型负性免疫调节因子。然而，TIPE2在稽留流产中的表达水平及临床意义尚不清楚。

方法

采用定量实时聚合酶链反应、蛋白质免疫印迹法及免疫组织化学法检测36例稽留流产患者和36例健康对照者蜕膜及绒毛中TIPE2 mRNA和蛋白的表达。此外，采用流式细胞术检测血清肿瘤坏死因子-α（TNF-α）和白细胞介素10（IL-10）水平。采用放射免疫分析法检测血清雌二醇和孕酮水平。进一步分析TIPE2蛋白水平与TNF-α、IL-10、雌二醇和孕酮的相关性。

结果

稽留流产患者蜕膜组织中TIPE2蛋白水平显著低于健康对照者。与健康对照者相比，稽留流产患者血清TNF-α水平显著升高，血清IL-10、雌二醇和孕酮水平降低。TIPE2蛋白水平与血清IL-10水平呈正相关。

结论

我们的数据表明，TIPE2可能在维持母胎耐受中发挥重要作用，蜕膜中TIPE2表达降低可能与稽留流产的发生有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/5576376/098adf0858a8/12958_2017_285_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/5576376/fead0af2ae4f/12958_2017_285_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/5576376/4a506c95aa05/12958_2017_285_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/5576376/bf8a43521190/12958_2017_285_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/5576376/4abe16bf64ce/12958_2017_285_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/5576376/098adf0858a8/12958_2017_285_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/5576376/fead0af2ae4f/12958_2017_285_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/5576376/4a506c95aa05/12958_2017_285_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/5576376/bf8a43521190/12958_2017_285_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/5576376/4abe16bf64ce/12958_2017_285_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/159d/5576376/098adf0858a8/12958_2017_285_Fig5_HTML.jpg

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Negative Immune Regulator TIPE2 Promotes M2 Macrophage Differentiation through the Activation of PI3K-AKT Signaling Pathway.负性免疫调节因子TIPE2通过激活PI3K-AKT信号通路促进M2巨噬细胞分化。
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