Ahrens R C, Milavetz G, Joad J
Chest. 1987 Jul;92(1 Suppl):15S-21S.
Increased airway responsiveness occurs in asthma, chronic bronchitis, cystic fibrosis, and other diseases. Theophylline and beta 2 agonists commonly are used as maintenance therapy for symptoms associated with the increased responsiveness. Both drugs can reduce airway responsiveness to a variety of provocational stimuli. With currently used dosing regimens, theophylline appears to produce relatively constant levels of effect on airway responsiveness and clinical efficacy around the clock, while inhaled beta 2 agonists appear to have insufficient effects at the end of longer dosing intervals. Improved dosing strategies for beta 2 agonists may improve the efficacy of these agents in the future.
气道反应性增加见于哮喘、慢性支气管炎、囊性纤维化及其他疾病。茶碱和β2激动剂通常用作与反应性增加相关症状的维持治疗。两种药物均可降低气道对多种激发刺激的反应性。按照目前使用的给药方案，茶碱似乎能全天对气道反应性和临床疗效产生相对稳定的作用水平，而吸入性β2激动剂在较长给药间隔结束时似乎作用不足。β2激动剂改进后的给药策略可能会在未来提高这些药物的疗效。
