Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, 514-8507, Japan.
Department of Orthopaedic Surgery, Fukui University Graduate School of Medicine, Fukui, 910-1104, Japan.
Sci Rep. 2017 Aug 29;7(1):9640. doi: 10.1038/s41598-017-08781-6.
The presence of systemic inflammation has been reported to be associated with poor prognosis in patients with soft tissue sarcoma (STS). The cytokine interleukin-6 (IL-6) has pleiotropic effects on various cell types in the tumor microenvironment. The aim of the present study was to determine whether serum IL-6 levels could be useful to assume the differentiation of benign soft tissue tumors from STS and to investigate the possible value of IL-6 for survival and oncological events in patients with STS. The medical records of 99 patients who underwent surgical resection were retrospectively reviewed. Serum IL-6 levels (median: 9.04 pg/ml) in patients with STS were statistically higher than those (3.31 pg/ml) in patients with benign soft tissue tumors. Our analyses confirmed that tumor size and IL-6 level were significant predictors of STS diagnosis. Next, we examined the relationship between IL-6 levels and survival in the 59 patients with STS. C-reactive protein levels, hemoglobin levels, and tumor grade were strongly correlated with IL-6 levels. Tumor grade and IL-6 level remained significant factors for survival and event-free survival. We suggest that measurement of IL-6 levels may be a useful method for identifying patients who are at a high risk of STS and tumor-related death.
系统炎症的存在与软组织肉瘤（STS）患者的预后不良有关。细胞因子白细胞介素 6（IL-6）对肿瘤微环境中的各种细胞类型具有多效性作用。本研究旨在确定血清 IL-6 水平是否可用于假设良性软组织肿瘤与 STS 的分化，并研究 IL-6 对 STS 患者生存和肿瘤事件的可能价值。回顾性分析了 99 例行手术切除的患者的病历。STS 患者的血清 IL-6 水平（中位数：9.04pg/ml）明显高于良性软组织肿瘤患者（3.31pg/ml）。我们的分析证实，肿瘤大小和 IL-6 水平是 STS 诊断的显著预测因子。接下来，我们检查了 59 例 STS 患者中 IL-6 水平与生存之间的关系。C 反应蛋白水平、血红蛋白水平和肿瘤分级与 IL-6 水平密切相关。肿瘤分级和 IL-6 水平仍然是生存和无事件生存的重要因素。我们建议，测量 IL-6 水平可能是一种有用的方法，可以识别患有 STS 和与肿瘤相关死亡风险高的患者。
