Yuenyongchaiwat Kornanong
Department of Physiotherapy, Faculty of Allied Health Sciences, Thammasat University, Klong Luang, Rangsit, Pathum Thani 12120, Thailand.
Indian J Psychol Med. 2017 Jul-Aug;39(4):413-417. doi: 10.4103/0253-7176.211744.
It has been proposed that increased physiological responses (i.e., cardiovascular reactivity) to a stressor or stressors may increase the risk of developing cardiovascular disease (CVD) including increased blood pressure (BP) or hypertension. However, many prospective studies have examined the hemodynamic reactions to laboratory stress tests and CVD in Western countries and only a few studies have examined with varying durations of follow-up in the same sample studies. In addition, still relatively little is known about cardiovascular reactivity in Asian populations. Therefore, the aim of this study was to examine whether cardiovascular responses to psychological stressors remained a significant predictor of 40-month follow-up among initially normotensive participants in Thailand, Asia.
Hemodynamic parameter was measured at rest, during, and after mental arithmetic, a speech task, and a cold pressor task. Ninety-five healthy normotensive male and female participants were reevaluated BP at 40 months later.
Regression analyses indicated that after adjustment for baseline BP, initial age, sex, body mass index, and family history of CVD, heightened systolic BP (SBP) responses to mental arithmetic was associated with increased future SBP (Δ = 0.04, = 0.023).
Therefore, these findings suggest that cardiovascular reactivity remains a prediction of future BP and may play a role in the development of hypertension and CVD.
有人提出，对一种或多种应激源的生理反应增强（即心血管反应性）可能会增加患心血管疾病（CVD）的风险，包括血压升高或患高血压。然而，许多前瞻性研究在西方国家考察了对实验室应激测试的血流动力学反应与心血管疾病的关系，只有少数研究在同一样本研究中进行了不同随访时长的考察。此外，对于亚洲人群的心血管反应性仍知之甚少。因此，本研究的目的是考察在亚洲泰国，最初血压正常的参与者中，心血管对心理应激源的反应是否仍是40个月随访的重要预测指标。
在静息状态、心算期间、心算后、言语任务期间、言语任务后、冷加压任务期间及冷加压任务后测量血流动力学参数。95名健康的血压正常的男性和女性参与者在40个月后重新评估血压。
回归分析表明，在对基线血压、初始年龄、性别、体重指数和心血管疾病家族史进行调整后，心算时收缩压（SBP）反应增强与未来收缩压升高相关（Δ = 0.04，P = 0.023）。
因此，这些发现表明心血管反应性仍是未来血压的预测指标，可能在高血压和心血管疾病的发展中起作用。
