Cameron I Wells, Gregory O'Grady, Ian P Bissett, Department of Surgery, University of Auckland, Auckland 1010, New Zealand.
World J Gastroenterol. 2017 Aug 14;23(30):5634-5644. doi: 10.3748/wjg.v23.i30.5634.
To critically review the literature addressing the definition, epidemiology, aetiology and pathophysiology of acute colonic pseudo-obstruction (ACPO).
A systematic search was performed to identify articles investigating the aetiology and pathophysiology of ACPO. A narrative synthesis of the evidence was undertaken.
No consistent approach to the definition or reporting of ACPO has been developed, which has led to overlapping investigation with other conditions. A vast array of risk factors has been identified, supporting a multifactorial aetiology. The pathophysiological mechanisms remain unclear, but are likely related to altered autonomic regulation of colonic motility, in the setting of other predisposing factors.
Future research should aim to establish a clear and consistent definition of ACPO, and elucidate the pathophysiological mechanisms leading to altered colonic function. An improved understanding of the aetiology of ACPO may facilitate the development of targeted strategies for its prevention and treatment.
批判性地回顾关于急性结肠假性梗阻（ACPO）的定义、流行病学、病因学和病理生理学的文献。
系统地搜索了调查 ACPO 病因学和病理生理学的文章。对证据进行了叙述性综合。
尚未制定出关于 ACPO 的定义或报告的一致方法，这导致与其他疾病的重叠调查。已经确定了大量的危险因素，支持多因素病因。病理生理机制仍不清楚，但可能与其他诱发因素下结肠运动的自主调节改变有关。
未来的研究应旨在建立 ACPO 的明确和一致的定义，并阐明导致结肠功能改变的病理生理机制。对 ACPO 病因的进一步了解可能有助于制定针对其预防和治疗的有针对性的策略。
