骨软骨瘤患病率的骨学研究
An Osteological Study on the Prevalence of Osteochondromas.
作者信息
Gaumer Gregory R, Weinberg Doug S, Collier Christopher D, Getty Patrick J, Liu Raymond W
机构信息
Division of Pediatric Orthopaedic Surgery Case Western Reserve University Rainbow Babies and Children's Hospital11100 Euclid Avenue, RBC 6081 Cleveland, OH 44106.
出版信息
Iowa Orthop J. 2017;37:147-150.
BACKGROUND
Osteochondromas are frequently reported to be the most common benign tumor of bone. However, there is not definitive data on their prevalence rate as they are often clinically silent, with previous studies estimating 1-3%.
METHODS
We examined a large osteologic collection of 2954 skeletons to identify likely osteochondromas. One author examined all bones excluding the skull in each skeleton for atypical cortical projections. These candidates were then evaluated by an orthopedic resident and then a fellowship trained pediatric orthopedic surgeon for final inclusion using strict criteria.
RESULTS
13 cases of osteochondroma were identified from 2954 skeletons to yield a prevalence of 0.44% (95% confidence interval 0.20% - 0.68%) in the study population. All were located on long bones: three in the humerus, six in the femur and four in the tibia.
CONCLUSIONS
We found a prevalence of 0.44% for osteochondromas, which is approximately half the lowest value reported in previous literature.
背景
骨软骨瘤常被报道为最常见的骨良性肿瘤。然而，由于它们通常在临床上无症状，目前尚无关于其患病率的确切数据，先前的研究估计患病率为1%-3%。
方法
我们检查了一个包含2954具骨骼的大型骨学标本集，以确定可能的骨软骨瘤。由一位作者检查每具骨骼中除颅骨外的所有骨骼，寻找非典型的皮质突起。然后由一名骨科住院医师对这些候选病例进行评估，最后由一名接受过 fellowship 培训的小儿骨科医生根据严格标准进行最终筛选以确定是否纳入。
结果
在2954具骨骼中发现了13例骨软骨瘤，在研究人群中的患病率为0.44%（95%置信区间0.20%-0.68%）。所有病例均位于长骨：肱骨3例，股骨6例，胫骨4例。
结论
我们发现骨软骨瘤的患病率为0.44%，约为先前文献报道的最低值的一半。
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