脑源性神经营养因子前体肽：一种通过蛋白水解加工从脑源性神经营养因子前体产生的新型突触调节剂，作为N端片段生成。
BDNF pro-peptide: a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing.
作者信息
Mizui Toshiyuki, Ohira Koji, Kojima Masami
机构信息
Biomedical Research Inst. (BMD), National Institute of Advanced Industrial Science and Technology (AIST), Osaka, Japan.
Core Research for Evolutional Science and Technology (CREST), Science and Technology Agency (JST), Kawaguchi, Japan.
出版信息
Neural Regen Res. 2017 Jul;12(7):1024-1027. doi: 10.4103/1673-5374.211173.
Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and pro-domain. However, compared with the expression and function of bioactive mature domain, the biological role of the pro-domain is poorly understood. Unexpectedly, we found that the pro-domain (or pro-peptide) of brain-derived neurotrophic factor (BDNF), which is well-known neurotrophic factor in brain, has a potential ability to facilitate hippocampal long-term depression. Furthermore, a BDNF polymorphism Val66Met, which substitute valine into methionine at 66 amino acid, impacted the biological activity of the BDNF pro-peptide. We lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.
大多数生长因子最初是以前体形式合成的，然后被切割成生物活性成熟结构域和前结构域。然而，与生物活性成熟结构域的表达和功能相比，前结构域的生物学作用却知之甚少。出乎意料的是，我们发现脑源性神经营养因子（BDNF）的前结构域（或前肽），一种在大脑中广为人知的神经营养因子，具有促进海马体长期抑制的潜在能力。此外，BDNF的一个多态性位点Val66Met，即在第66个氨基酸处将缬氨酸替换为甲硫氨酸（蛋氨酸），影响了BDNF前肽的生物活性。我们最后讨论了BDNF及其前肽在神经干细胞生成和缺血进展中的可能作用。
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