Duan Xiaoqin, Yao Gang, Liu Zhongliang, Cui Ranji, Yang Wei
Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, China.
Front Hum Neurosci. 2018 May 30;12:215. doi: 10.3389/fnhum.2018.00215. eCollection 2018.
Post-stroke depression (PSD) is a neuropsychiatric affective disorder that can develop after stroke. Patients with PSD show poorer functional and recovery outcomes than patients with stroke who do not suffer from depression. The risk of suicide is also higher in patients with PSD. PSD appears to be associated with complex pathophysiological mechanisms involving both psychological and psychiatric problems that are associated with functional deficits and neurochemical changes secondary to brain damage. Transcranial magnetic stimulation (TMS) is a non-invasive way to investigate cortical excitability via magnetic stimulation of the brain. TMS is currently a valuable tool that can help us understand the pathophysiology of PSD. Although repetitive TMS (rTMS) is an effective treatment for patients with PSD, its mechanism of action remains unknown. Here, we review the known mechanisms underlying rTMS as a tool for better understanding PSD pathophysiology. It should be helpful when considering using rTMS as a therapeutic strategy for PSD.
中风后抑郁症（PSD）是一种中风后可能发生的神经精神性情感障碍。与未患抑郁症的中风患者相比，PSD患者的功能和恢复结果更差。PSD患者的自杀风险也更高。PSD似乎与复杂的病理生理机制有关，涉及与功能缺陷以及脑损伤继发的神经化学变化相关的心理和精神问题。经颅磁刺激（TMS）是一种通过磁刺激大脑来研究皮质兴奋性的非侵入性方法。TMS目前是一种有价值的工具，可帮助我们了解PSD的病理生理学。尽管重复经颅磁刺激（rTMS）是治疗PSD患者的有效方法，但其作用机制仍不清楚。在此，我们综述rTMS作为一种工具用于更好地理解PSD病理生理学的已知机制。在考虑将rTMS用作PSD的治疗策略时，这应该会有所帮助。
