脊髓损伤会引发慢性脑部变化。
Spinal cord injury drives chronic brain changes.
作者信息
Jure Ignacio, Labombarda Florencia
机构信息
Laboratorio de Bioquímica Neuroendocrina, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina.
Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
出版信息
Neural Regen Res. 2017 Jul;12(7):1044-1047. doi: 10.4103/1673-5374.211177.
Abstract
Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents. Regarding the hippocampus, neurogenesis is reduced and reactive gliosis increased. These long-term abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.
摘要
尽管已有报道称脊髓损伤患者存在认知障碍，但仅有少数研究考虑了脊髓损伤后感觉和运动皮层以外的脑结构变化。脊髓损伤会导致啮齿动物出现慢性脑神经炎症，进而引发神经退行性变和认知衰退。关于海马体，神经发生减少，反应性胶质增生增加。这些长期异常情况可能解释了脊髓创伤患者所表现出的行为障碍。
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