脊髓损伤会引发慢性脑部变化。
Spinal cord injury drives chronic brain changes.
作者信息
Jure Ignacio, Labombarda Florencia
机构信息
Laboratorio de Bioquímica Neuroendocrina, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina.
Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
出版信息
Neural Regen Res. 2017 Jul;12(7):1044-1047. doi: 10.4103/1673-5374.211177.
Abstract
Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents. Regarding the hippocampus, neurogenesis is reduced and reactive gliosis increased. These long-term abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.
摘要
尽管已有报道称脊髓损伤患者存在认知障碍，但仅有少数研究考虑了脊髓损伤后感觉和运动皮层以外的脑结构变化。脊髓损伤会导致啮齿动物出现慢性脑神经炎症，进而引发神经退行性变和认知衰退。关于海马体，神经发生减少，反应性胶质增生增加。这些长期异常情况可能解释了脊髓创伤患者所表现出的行为障碍。
相似文献
1
Spinal cord injury drives chronic brain changes.
Neural Regen Res. 2017 Jul;12(7):1044-1047. doi: 10.4103/1673-5374.211177.
2
Brain and spinal cord trauma: what we know about the therapeutic potential of insulin growth factor 1 gene therapy.
Neural Regen Res. 2023 Feb;18(2):253-257. doi: 10.4103/1673-5374.343902.
3
Spinal Cord Injury Impairs Neurogenesis and Induces Glial Reactivity in the Hippocampus.
Neurochem Res. 2017 Aug;42(8):2178-2190. doi: 10.1007/s11064-017-2225-9. Epub 2017 Mar 13.
4
Potential role of hippocampal neurogenesis in spinal cord injury induced post-trauma depression.
Neural Regen Res. 2024 Oct 1;19(10):2144-2156. doi: 10.4103/1673-5374.392855. Epub 2024 Jan 8.
5
Long-term neuroplasticity in spinal cord injury patients: a study on movement-related brain potentials.
Int J Psychophysiol. 2013 Feb;87(2):205-14. doi: 10.1016/j.ijpsycho.2013.01.012. Epub 2013 Jan 30.
6
Administration of low dose estrogen attenuates gliosis and protects neurons in acute spinal cord injury in rats.
J Neurochem. 2016 Mar;136(5):1064-73. doi: 10.1111/jnc.13464. Epub 2016 Jan 26.
7
Repeated mild lateral fluid percussion brain injury in the rat causes cumulative long-term behavioral impairments, neuroinflammation, and cortical loss in an animal model of repeated concussion.
J Neurotrauma. 2012 Jan 20;29(2):281-94. doi: 10.1089/neu.2011.2123. Epub 2011 Nov 8.
8
Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish.
Neural Dev. 2018 Nov 17;13(1):24. doi: 10.1186/s13064-018-0122-9.
9
MR Spectroscopy of the Cervical Spinal Cord in Chronic Spinal Cord Injury.
Radiology. 2019 Apr;291(1):131-138. doi: 10.1148/radiol.2018181037. Epub 2019 Jan 29.
10
Spinal cord injury in hypertonic newborns after antenatal hypoxia-ischemia in a rabbit model of cerebral palsy.
Exp Neurol. 2017 Jul;293:13-26. doi: 10.1016/j.expneurol.2017.03.017. Epub 2017 Mar 24.
引用本文的文献
1
Extracellular vesicle-mediated spinal cord-brain crosstalk induces hippocampal neurogenesis impairment and cognitive deficits post-spinal cord injury.
Theranostics. 2025 Jun 23;15(15):7584-7606. doi: 10.7150/thno.110560. eCollection 2025.
2
Enhancing Functional Recovery After Spinal Cord Injury Through Neuroplasticity: A Comprehensive Review.
Int J Mol Sci. 2025 Jul 9;26(14):6596. doi: 10.3390/ijms26146596.
3
Olfactory Ensheathing Cell Ameliorate Neuroinflammation Following Spinal Cord Injury Through Upregulating REV-ERBα in Microglia.
Cell Transplant. 2024 Jan-Dec;33:9636897241261234. doi: 10.1177/09636897241261234.
4
Refinement of the motorised laminectomy-assisted rat spinal cord injury model by analgesic treatment.
PLoS One. 2024 Jan 16;19(1):e0294720. doi: 10.1371/journal.pone.0294720. eCollection 2024.
5
Brain MRI changes in degenerative cervical myelopathy: a systematic review.
EBioMedicine. 2024 Jan;99:104915. doi: 10.1016/j.ebiom.2023.104915. Epub 2023 Dec 19.
6
Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury.
J Mol Neurosci. 2023 Oct;73(9-10):724-737. doi: 10.1007/s12031-023-02151-w. Epub 2023 Aug 30.
7
Metabolic profile of complete spinal cord injury in pons and cerebellum: A 3T 1H MRS study.
Sci Rep. 2023 May 4;13(1):7245. doi: 10.1038/s41598-023-34326-1.
8
Depolarization and Hyperexcitability of Cortical Motor Neurons after Spinal Cord Injury Associates with Reduced HCN Channel Activity.
Int J Mol Sci. 2023 Mar 1;24(5):4715. doi: 10.3390/ijms24054715.
9
Paths to hippocampal damage in neuromyelitis optica spectrum disorders.
Neuropathol Appl Neurobiol. 2023 Apr;49(2):e12893. doi: 10.1111/nan.12893.
10
Microglial activation in the motor cortex mediated NLRP3-related neuroinflammation and neuronal damage following spinal cord injury.
Front Cell Neurosci. 2022 Oct 20;16:956079. doi: 10.3389/fncel.2022.956079. eCollection 2022.
本文引用的文献
1
Chemokines in neuron-glial cell interaction and pathogenesis of neuropathic pain.
Cell Mol Life Sci. 2017 Sep;74(18):3275-3291. doi: 10.1007/s00018-017-2513-1. Epub 2017 Apr 7.
2
Spinal Cord Injury Impairs Neurogenesis and Induces Glial Reactivity in the Hippocampus.
Neurochem Res. 2017 Aug;42(8):2178-2190. doi: 10.1007/s11064-017-2225-9. Epub 2017 Mar 13.
3
Endoplasmic Reticulum Stress and Disrupted Neurogenesis in the Brain Are Associated with Cognitive Impairment and Depressive-Like Behavior after Spinal Cord Injury.
J Neurotrauma. 2016 Nov 1;33(21):1919-1935. doi: 10.1089/neu.2015.4348. Epub 2016 May 16.
4
Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation.
Cold Spring Harb Perspect Biol. 2015 Sep 1;7(9):a021303. doi: 10.1101/cshperspect.a021303.
5
Inflammation is increased with anxiety- and depression-like signs in a rat model of spinal cord injury.
Brain Behav Immun. 2016 Jan;51:176-195. doi: 10.1016/j.bbi.2015.08.009. Epub 2015 Aug 18.
6
Neuroglial Transmission.
Physiol Rev. 2015 Jul;95(3):695-726. doi: 10.1152/physrev.00024.2014.
7
Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury.
Br J Pharmacol. 2016 Feb;173(4):681-91. doi: 10.1111/bph.13179. Epub 2015 Jun 12.
8
Prospective study of the occurrence of psychological disorders and comorbidities after spinal cord injury.
Arch Phys Med Rehabil. 2015 Aug;96(8):1426-34. doi: 10.1016/j.apmr.2015.02.027. Epub 2015 Mar 14.
9
Isolated spinal cord contusion in rats induces chronic brain neuroinflammation, neurodegeneration, and cognitive impairment. Involvement of cell cycle activation.
Cell Cycle. 2014;13(15):2446-58. doi: 10.4161/cc.29420.
10
Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways.
J Neurosci. 2014 Aug 13;34(33):10989-1006. doi: 10.1523/JNEUROSCI.5110-13.2014.
Zotero 插件