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Neuroregeneration using cellular reprogramming.

作者信息

Nguyen Tu, Wong Raymond Ching-Bong

机构信息

Centre for Eye Research Australia, East Melbourne, VIC, Australia; Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC, Australia.

出版信息

Neural Regen Res. 2017 Jul;12(7):1073-1074. doi: 10.4103/1673-5374.211182.

DOI:10.4103/1673-5374.211182
PMID:28852386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5558483/
Abstract
摘要

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Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells.基于CRISPR/Cas9的转录激活因子对内源基因座进行靶向表观遗传重塑可直接将成纤维细胞转化为神经元细胞。
Cell Stem Cell. 2016 Sep 1;19(3):406-14. doi: 10.1016/j.stem.2016.07.001. Epub 2016 Aug 11.
2
Reprogramming Müller glia via in vivo cell fusion regenerates murine photoreceptors.通过体内细胞融合对穆勒胶质细胞进行重编程可使小鼠光感受器再生。
J Clin Invest. 2016 Aug 1;126(8):3104-16. doi: 10.1172/JCI85193. Epub 2016 Jul 18.
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Transgenic expression of the proneural transcription factor Ascl1 in Müller glia stimulates retinal regeneration in young mice.在缪勒胶质细胞中过表达神经前体转录因子Ascl1可刺激幼鼠视网膜再生。
Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13717-22. doi: 10.1073/pnas.1510595112. Epub 2015 Oct 19.
4
Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.小分子可有效将人星形胶质细胞重编程为功能性神经元。
Cell Stem Cell. 2015 Dec 3;17(6):735-747. doi: 10.1016/j.stem.2015.09.012. Epub 2015 Oct 17.
5
Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex.Sox2 介导将 NG2 神经胶质细胞在成年大脑皮质损伤中转化为诱导神经元。
Stem Cell Reports. 2014 Dec 9;3(6):1000-14. doi: 10.1016/j.stemcr.2014.10.007. Epub 2014 Nov 20.
6
In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model.脑损伤和阿尔茨海默病模型中反应性神经胶质细胞在体直接重编程为功能性神经元。
Cell Stem Cell. 2014 Feb 6;14(2):188-202. doi: 10.1016/j.stem.2013.12.001. Epub 2013 Dec 19.
7
In vivo reprogramming of astrocytes to neuroblasts in the adult brain.在成年大脑中将星形胶质细胞重编程为神经前体细胞。
Nat Cell Biol. 2013 Oct;15(10):1164-75. doi: 10.1038/ncb2843. Epub 2013 Sep 22.
8
Generation of induced neurons via direct conversion in vivo.体内直接转化生成诱导神经元。
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7038-43. doi: 10.1073/pnas.1303829110. Epub 2013 Mar 25.
9
In vivo reprogramming of Sox9+ cells in the liver to insulin-secreting ducts.在体重编程 Sox9+ 细胞为胰岛素分泌导管。
Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15336-41. doi: 10.1073/pnas.1201701109. Epub 2012 Sep 4.
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Nature. 2012 May 31;485(7400):593-8. doi: 10.1038/nature11044.