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靶细胞糖基化决定植物凝集素相思子毒素的生物分布。

Target Cell Glycosylation Determines the Biodistribution of Plant Lectin Viscumin.

作者信息

Maltseva D V, Gerasimov V M, Sakharov D A, Shkurnikov M Yu

机构信息

BioClinicum Research Center, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2017 Aug;163(4):482-485. doi: 10.1007/s10517-017-3833-8. Epub 2017 Aug 29.

DOI:10.1007/s10517-017-3833-8
PMID:28853065
Abstract

We studied the possibility of using viscumin lectin (MLI) for targeted delivery of antitumor drugs. Affinity of MLI for more than 600 oligosaccharide structures was determined and the glycosylation profiles of cell surface in various mouse tissues were analyzed. It was found that biodistribution of MLI was determined by not only expression of oligosaccharides specifically recognized by the lectin in tissue cells, but also by the structure of glycan in general.

摘要

我们研究了使用相思豆毒素凝集素（MLI）进行抗肿瘤药物靶向递送的可能性。测定了MLI对600多种寡糖结构的亲和力，并分析了各种小鼠组织中细胞表面的糖基化谱。结果发现，MLI的生物分布不仅取决于组织细胞中凝集素特异性识别的寡糖的表达，还取决于聚糖的总体结构。

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