Kuklina Е М, Nekrasova I V, Valieva Yu V
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia.
Bull Exp Biol Med. 2017 Aug;163(4):447-450. doi: 10.1007/s10517-017-3825-8. Epub 2017 Aug 29.
The involvement of endogenous semaphorin (Sema4D) into the key stage of T-dependent differentiation of B cells, formation of plasmoblasts, was demonstrated in vitro in T/B cell co-culture under conditions of polyclonal activation of T cells. The effect of semaphorin was not associated with activation of high-affinity Sema4D receptor plexin B1, but involves lowaffinity receptor CD72. These data indicate that Sema4D-dependent signal regulates not only the initial stage of B-cell activation, proliferative response to the antigen, but also further differentiation of B cells into plasma cells.
在内源性信号素（Sema4D）参与B细胞依赖T细胞分化的关键阶段即成浆细胞形成方面，已在T细胞多克隆激活条件下的T/B细胞共培养体系中得到体外证实。信号素的作用与高亲和力Sema4D受体丛状蛋白B1的激活无关，而是涉及低亲和力受体CD72。这些数据表明，依赖Sema4D的信号不仅调节B细胞激活的初始阶段、对抗原的增殖反应，还调节B细胞进一步分化为浆细胞的过程。
