[巨噬细胞功能及其抗炎和促消退活性在牙周炎发展中的进展]
[Advances in macrophage function and its anti-inflammatory and proresolving activity and role in periodontitis development].
作者信息
Lin Bai, Yuejiao Xin, Dingyu Duan, Yi Xu
机构信息
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Aug 1;35(4):427-432. doi: 10.7518/hxkq.2017.04.016.
Macrophage plays an important role in human innate immune system. It has powerful functions, such as recognition, phagocytosis, and bacteria and foreign body removal. Periodontitis, which is a chronic infectious disease characterized by gum inflammation and bone loss, is a major cause of tooth loss in adults. Several studies demonstrated that periodontal tissue destruction is caused by the host immune response defending against infections. As an important part of host immune response, macrophage is also involved in periodontitis pathogenesis. Recently, anti-inflammatory and proresolving activities of macrophage was discovered. Thus, the complex function of macrophage in the occurrence, development, and resolution of inflammation and its potential role in periodontitis were reviewed.
巨噬细胞在人类固有免疫系统中发挥着重要作用。它具有强大的功能，如识别、吞噬以及清除细菌和异物。牙周炎是一种以牙龈炎症和骨质流失为特征的慢性感染性疾病，是成年人牙齿缺失的主要原因。多项研究表明，牙周组织破坏是由宿主抵御感染的免疫反应所引起的。作为宿主免疫反应的重要组成部分，巨噬细胞也参与了牙周炎的发病机制。最近，发现了巨噬细胞的抗炎和促炎症消退活性。因此，本文综述了巨噬细胞在炎症发生、发展和消退过程中的复杂功能及其在牙周炎中的潜在作用。
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